|Titre :||A genome-wide search for quantitative trait loci that influence antisocial drug dependence in adolescence|
|Titre traduit :||A genome-wide search for quantitative trait Loci that influence antisocial drug dependence in adolescence ; (Une recherche à travers le génome sur les Quantitative Trait Loci qui influencent la dépendance antisociale aux drogues à l'adolescence)|
|Auteurs :||M. C. STALLINGS ; R. P. CORLEY ; B. DENNEHEY ; J. K. HEWITT ; K. S. KRAUTER ; J. M. LESSEM ; S. K. MIKULICH-GILBERTSON ; S. H. RHEE ; A. SMOLEN ; S. E. YOUNG ; T. J. CROWLEY|
|Type de document :||Périodique|
|Année de publication :||2005|
|Note générale :||
Archives of General Psychiatry, 2005, 62, (9), 1042-1051
|Discipline :||PAT (Pathologie organique / Organic pathology)|
Thésaurus TOXIBASEGENETIQUE ; METHODE ; DEPENDANCE ; FACTEUR DE VULNERABILITE ; ADOLESCENT ; MESURES QUALITATIVES
|Résumé :||BACKGROUND: Among adolescents, externalizing problem behavior and substance use disorders are often comorbid. Familial influences, including shared genetic risk factors, may account for part of this comorbidity. Previously we reported 2 chromosomal regions (3q24-3q25 and 9q34) likely to contain genes that influence substance dependence vulnerability (DV) in adolescence. OBJECTIVES: To identify quantitative trait loci (QTLs) that influence externalizing problem behavior in adolescence and to determine whether any identified QTL overlap chromosomal regions that influence DV. DESIGN: Regression-based QTL mapping procedures designed for selected sibling pair samples. SETTING: Patient probands were drawn from consecutive admissions to residential and outpatient (milieu-type) treatment facilities for substance abuse and delinquency operated by the University of Colorado; most of these patients were referred for treatment by juvenile justice or social service agencies. PATIENTS: A total of 249 proband-sibling pairs from 191 families were selected for the study. Patient probands were 13 to 19 years of age; siblings of the probands ranged in age from 12 to 25 years. MAIN OUTCOME MEASURES: A community-based sample of 4493 adolescents and young adults was used to define clinically significant, heritable, age- and sex-normed indexes of DV, conduct disorder symptoms (CDS), and a composite index of antisocial substance dependence (DV + CDS). Siblings and parents were genotyped for 374 microsatellite markers distributed across the 22 autosomes (mean intermarker distance, 9.2 centimorgans). RESULTS: For both DV and CDS, there was evidence of linkage to the same region on chromosome 9q34, as well as to 3q24-3q25 for DV, and a novel region on chromosome 17q12 for CDS. Our composite index (DV + CDS) yielded the strongest evidence for linkage (logarithm of odds = 2.65) to the chromosome 9q34 region. CONCLUSION: These results provide the first evidence of a potential molecular genetic basis for the comorbidity between DV and antisocial behavior.|
|Domaine :||Plusieurs produits / Several products|
|Refs biblio. :||82|
Institute for Behavioral Genetics and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 80309-0444.
Etats-Unis. United States.
|Numéro Toxibase :||1301616|
|Centre Emetteur :||13 OFDT|