| Titre : | Effects of varying marijuana potency on deposition of tar and delta9-THC in the lung during smoking |
| Titre traduit : | (Les effets de la variation en principes actifs de la marijuana sur la déposition de goudron et de delta9-THC dans les poumons durant la consommation.) |
| Auteurs : | MATTHIAS P. ; TASHKIN D. P. ; J. A. MARQUES-MAGALLANES ; J. N. WILKINS ; SIMMONS M .S. |
| Type de document : | Périodique |
| Année de publication : | 1997 |
| Format : | 1145-1150 |
| Note générale : |
Pharmacology, Biochemistry and Behavior, 1997, 58, (4), 1145-1150 |
| Langues: | Français |
| Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
| Mots-clés : |
Thésaurus mots-clés CANNABIS ; TETRAHYDROCANNABINOL ; ANALYSE CHIMIQUE ; FUMER ; GOUDRONS ; POUMONThésaurus géographique ETATS-UNIS |
| Résumé : |
ENGLISH : To determine whether smoking more, compared to less, potent marijuana (MJ) cigarettes to a desired level of intoxication ("high") reduces pulmonary exposure to noxious smoke components, in 10 habitual smokers of MJ, we measured respiratory delivery and deposition of tar and delta9-tetrahydrocannabinol (THC), carboxyhemoglobin (COHb) boost, smoking topography, including cumulative puff volume (CPV) and breathholding time, change in heart rate (deltaHR) and "high" during ad lib smoking of 0, 1.77, and 3.95% MJ cigarettes on 3 separate days. At each session, subjects had access to only a single MJ cigarette. On average, smoking topography and COHb boost did not differ across the different strengths of MJ, while THC delivery, as well as HR, were significantly greater (p |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 16 |
| Affiliation : |
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 Etats-Unis. United States. |
| Centre Emetteur : | 13 OFDT |
| Cote : | A03078 |
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