Titre : | Effects of delta-9-tetrahydrocannabinol, the primary psychoactive cannabinoid in marijuana, on human sperm function in vitro |
Titre traduit : | (Les effets du delta-9-tetrahydrocannabinol, le cannabinoïde psychoactif de la marijuana, sur la fonction spermatique humaine in vitro.) |
Auteurs : | WHAN L. B. ; M. C. WEST ; N. McCLURE ; S. E. LEWIS |
Type de document : | Périodique |
Année de publication : | 2006 |
Format : | 653-660 |
Note générale : |
Fertility and Sterility, 2006, 85, (3), 653-660 |
Langues: | Français |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés SEXE MASCULIN ; REPRODUCTION ; TETRAHYDROCANNABINOL ; CANNABIS ; SPERME |
Résumé : |
ENGLISH : OBJECTIVE: To investigate effects of delta-9-tetrahydrocannabinol (THC) on human sperm function in vitro. DESIGN: Laboratory analysis of sperm motility after exposure to THC using computer-assisted semen analysis and acrosome reaction by fluoroscein isothiocyanate-labeled peanut agglutinin staining. SETTING: An assisted reproductive technology unit. PATIENT(S): Seventy-eight male patients. INTERVENTION(S): Sperm were divided into 90% (the best fertilizing potential used in assisted conception) and 45% (the poorer subpopulation) fractions by density centrifugation and incubated with THC at concentrations equivalent to therapeutic (0.032 uM) and recreational (0.32 and 4.8 uM) plasma levels at 37°C for 3 h. MAIN OUTCOME MEASURE(S): Sperm motility and spontaneous and induced acrosome reactions. RESULT(S): Percentage progressive motility was decreased dose dependently in the 90% fraction (by 2%-21%; P<.05 p the fraction showed a greater decrease in percentage progressive motility at um and res straight line velocity average path also were reduced layer both fractions. spontaneous acrosome reactions resp more markedly fractions when reaction was artificially induced by a23187 thc resulted inhibition conclusion use of as recreational drug may adversely affect male fertility. s abstract> |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 73 |
Affiliation : |
Obstetrics & Gynaecology, School of Medicine, Queen's University, Belfast Royaume-Uni. United Kingdom. |
Centre Emetteur : | 13 OFDT |
Cote : | A03109 |
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