Titre : | Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study |
Titre traduit : | (Avoir reconnu un usage de cannabis est un facteur de risque de schizophrénie chez les conscrits suédois de 1969 : une étude historique de cohorte.) |
Auteurs : | S. ZAMMIT ; P. ALLEBECK ; S. ANDREASSON ; I. LUNDBERG ; G. LEWIS |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 1199-1201 / tabl. |
Note générale : |
British Medical Journal, 2002, 325, 1199-1201 |
Langues: | Français |
Mots-clés : |
Thésaurus mots-clés CANNABIS ; SCHIZOPHRENIE ; FACTEUR DE RISQUE ; ETUDE RETROSPECTIVEThésaurus géographique SUEDE |
Résumé : |
ENGLISH : Objectives: An association between use of cannabis in adolescence and subsequent risk of schizophrenia was previously reported in a follow up of Swedish conscripts. Arguments were raised that this association may be due to use of drugs, other than cannabis and that personality traits may have confounded results. We performed a further analysis of this cohort to address these uncertainties while extending the follow up period to identify additional cases. Design: Historical cohort study. Setting 1969-70 survey of Swedish conscripts (>97% of the countrys male population aged 18-20). Participants: 50 087 subject: data were available on self reported use of cannabis and other drugs, and on several social and psychological characteristics. Main outcome measures: Admissions to hospital for ICD-8/9 schizophrenia and other psychoses, as determined by record linkage. Results: Cannabis was associated with an increased risk of developing schizophrenia in a dose dependent fashion both for subjects who had ever used cannabis (adjusted odds ratio for linear trend of increasing frequency 1.2, 95% confidence interval 1.1 to 1.4, P 50 times was 6.7 (2.1 to 21.7) in the cannabis only group. Similar results were obtained when analysis was restricted to subjects developing schizophrenia after five years after conscription to exclude prodromal cases. Conclusions: Cannabis use is associated with in increased risk of developing schizophrenia, consistent with a causal relation. This association is not explained by use of other psychoactive drugs or personality traits relating to social integration. (Author' s abstract) |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 20 |
Affiliation : |
Dprt of Psychological Medicine, Univ. of Wales, College of Medicine, Cardiff CF14 4XN Royaume-Uni. United Kingdom. |
Numéro Toxibase : | 206480 |
Centre Emetteur : | 02 Coordonnateur |
Cote : | A03128 |
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