Périodique
Caffeine intake, toxicity and dependence and lifetime risk for psychiatric and substance use disorders: an epidemiologic and co-twin control analysis
(Consommation de caféine, toxicité, dépendance et risque de troubles psychiatriques et de troubles liés à l'usage de substances au cours de la vie : une analyse épidémiologique et sur des jumeaux.)
Auteur(s) :
KENDLER, K. S. ;
MYERS, J. ;
GARDNER, C. O.
Année :
2006
Page(s) :
1717-1725
Langue(s) :
Français
Refs biblio. :
36
Domaine :
Plusieurs produits / Several products
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
CAFEINE
;
FRATRIE
;
FACTEUR DE RISQUE
;
PSYCHOPATHOLOGIE
;
TOXICITE
;
DEPENDANCE
;
EPIDEMIOLOGIE
;
ALCOOL
;
CANNABIS
;
COCAINE
Thésaurus géographique
ETATS-UNIS
Note générale :
Psychological Medicine, 2006, 36, (12), 1717-1725
Résumé :
ENGLISH :
BACKGROUND: Although caffeine is the most commonly used psychoactive substance and often produces symptoms of toxicity and dependence ; little is known ; especially in community samples ; about the association between caffeine use ; toxicity and dependence and risk for common psychiatric and substance use disorders. METHOD: Assessments of lifetime maximal caffeine use and symptoms of caffeine toxicity and dependence were available on over 3600 adult twins ascertained from the population-based Virginia Twin Registry. Lifetime histories of major depression (MD) ; generalized anxiety disorder (GAD) and panic disorder ; alcohol dependence ; adult antisocial behavior and cannabis and cocaine abuse/dependence were obtained at personal interview. Logistic regression analyses in the entire sample and within monozygotic (MZ) twin pairs were conducted in SAS. RESULTS: In the entire sample ; measures of maximal caffeine use ; heavy caffeine use ; and caffeine-related toxicity and dependence were significantly and positively associated with all seven psychiatric and substance use disorders. However ; within MZ twin pairs ; controlling for genetic and family environmental factors ; these associations ; while positive ; were all non-significant. These results were similar when excluding twins who denied regular caffeine use. CONCLUSIONS: Maximal lifetime caffeine intake and caffeine-associated toxicity and dependence are moderately associated with risk for a wide range of psychiatric and substance use disorders. Analyses of these relationships within MZ twin pairs suggest that most of the observed associations are not causal. Rather ; familial factors ; which are probably in part genetic ; predispose to both caffeine intake ; toxicity and dependence and the risk for a broad array of internalizing and externalizing disorders. (Author' s abstract)
Affiliation :
Virginia Institute of Psychiatric and Behavioral Genetics ; Medical College of Virginia/Virginia Commonwealth University ; Richmond ; VA 23298-0126. Email : Kendler@vcu.edu
Etats-Unis. United States.
Etats-Unis. United States.
Cote :
A03138