Titre : | Single dose of 24 milligrams of buprenorphine for heroin detoxification : an open-label study of five inpatients (2006) |
Titre traduit : | (Dose simple de 24 milligrammes de buprénorphine pour le sevrage de l'héroïne : étude non masquée de 5 patients hospitalisés) |
Auteurs : | K. ANG-LEE ; ORESKOVITCH M.R. ; A. J. SAXON ; JAFFE C. ; C. MEREDITH ; M. ELLIS ; MALTE C.A. ; P. C. KNOX |
Type de document : | Article : Périodique |
Dans : | Journal of Psychoactive Drugs (Vol.38 n°4, 2006) |
Article en page(s) : | 505-512 |
Note générale : |
Journal of Psychoactive Drugs, 2006, 38, (4), 505-512 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; DOSE-REPONSE ; SYNDROME DE SEVRAGE ; TRAITEMENT DE MAINTENANCE |
Résumé : |
ENGLISH : Previous studies indicate that buprenorphine has efficacy in medically supervised opioid withdrawal, but the optimal dosing for maximum tolerability and ease of administration remains undetermined. Five heroin-dependent individuals entered this open-label study of inpatient detoxification with a single 24mg dose of buprenorphine. The mean Clinical Opiate Withdrawal Scale (COWS) score prior to buprenorphine administration was 17.6 (SD = 3.36). COWS scores declined significantly thereafter. There was one episode of precipitated withdrawal that resolved within four hours. Use of ancillary medications was minimal. This study suggests that a single high dose of buprenorphine can be used safely and effectively for inpatient detoxification. |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 23 |
Affiliation : | Etats-Unis. United States. |
Numéro Toxibase : | 1301919 |
Centre Emetteur : | 13 OFDT |
Cote : | Abonnement |
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