| Titre : | Case-control study of non-Hodgkin's lymphoma among women and heterosexual men in the San Francisco Bay Area, California |
| Auteurs : | HOLLY E. A. ; LELE C. ; BRACCI P. M. ; M. S. MCGRATH |
| Type de document : | Périodique |
| Année de publication : | 1999 |
| Format : | 375-389 |
| Note générale : |
American Journal of Epidemiology, 1999, 150, (4), 375-389 |
| Langues: | Anglais |
| Mots-clés : |
Thésaurus TOXIBASE ALLERGIE ; ETUDE CAS-TEMOINS ; IMMUNOLOGIE ; SYSTEME IMMUNITAIRE ; FACTEUR DE RISQUE ; VIRUS ; LYMPHOCYTES ; CANNABISThésaurus Géographique ETATS-UNIS |
| Résumé : |
ENGLISH : A population-based case-control study was conducted between 1988 and 1995 in the San Francisco Bay Area of California to determine risk factors for non-Hodgkin's lymphoma. Participants completed in-person interviews, and blood was drawn to test for viruses and lymphocyte subsets. This report includes data for 1,281 cases and 2,095 controls. In multivariate analyses, the factors associated with a decreased risk for non-Hodgkin's lymphoma were allergy to plants, bee and wasp stings, five or more vaccinations, drugs to lower blood cholesterol, nonsteroidal anti-inflammatory drugs, total number of sexual partners, and lifetime marijuana use, whereas an increased risk was associated with cimetidine and other histamine H2-receptor antagonists, splenectomy, gonorrhea, and body mass index. Unique to sex-specific models was an increased risk for endocrine gland disorders among women and for polio among men. Median CD3, CD4, CD8, CD20, and lymphocyte counts for non-Hodgkin's lymphoma patients were significantly lower than those for controls. These results implicate environmental factors that may influence the early stages of lymphomagenesis by stimulating the immune system. Antigen-driven B cells that accumulate to form lymphoma may be suppressed by immunologic stresses such as exposure to an increased number of sexual partners and to certain medications. A history of allergies provides evidence for a persistent capacity for B-cell differentiation and therefore a decreased accumulation of B cells. The decreased risk for non-Hodgkin's lymphoma with use of nonsteroidal anti-inflammatory drugs and cholesterol-lowering drugs is consistent with a macrophage inflammatory role in B-cell proliferation. (Author' s abstract) |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 69 |
| Affiliation : |
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco Etats-Unis. United States. |
| Centre Emetteur : | 13 OFDT |
| Cote : | A03163 |
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