Historique
Article de Périodique
Buprenorphine mortality, seizures and prescription data in the UK, 1980-2002 (2005)
(Buprénorphine : mortalité, saisies et données de prescription au Royaume-Uni, 1980-2002.)
Auteur(s) :
SCHIFANO, F. ;
CORKERY, J. ;
GILVARRY, E. ;
DELUCA, P. ;
OYEFESO, A. ;
GHODSE, A. H.
Année :
2005
Page(s) :
343-348
Langue(s) :
Anglais
Domaine :
Autres substances / Other substances
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
BUPRENORPHINE
;
MORTALITE
;
SAISIE
;
EVOLUTION
;
PRESCRIPTION MEDICALE
Thésaurus géographique
ROYAUME-UNI
Résumé :
Buprenorphine safety in overdose has been debated recently, but no mortality data related to this compound from the UK have been published. To gather together all of the buprenorphine mortality figures, a number of different sources have been checked. To inform on buprenorphine safety issues, accessible information related to its availability indicators (i.e. prescriptions; seizures) data for the 1980-2002 time frame have been sought. In the UK, during this period, buprenorphine was mentioned in 43 fatalities. Typically, victims were males in the 25-44 age group. In 12 cases (28% of total), a verdict of suicide was given. Buprenorphine was detected on its own in seven cases; more frequently, it was found together with benzodiazepines and other opiates. Large quantities of buprenorphine were prescribed both in England in 1985-1989 and in 1991-1992 in Scotland, where seizures reached their highest levels. Buprenorphine prescriptions seemed to peak again after 1999, when high dose buprenorphine formulations entered the UK market. No positive correlation was found between the number of buprenorphine deaths over the years and either buprenorphine dispensings/prescriptions or seizures. However, an increase in buprenorphine-related deaths since 1999 was identified and this may be an issue which should be carefully monitored over the next few years. (Author's abstract)
Affiliation :
National Programme on Substance Abuse Deaths, Department of Mental Health-Addictive Behaviour, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE
Royaume-Uni. United Kingdom.
Royaume-Uni. United Kingdom.
Cote :
A03365