Titre : | Vaccine immunogenicity in injecting drug users: a systematic review |
Titre traduit : | (Immunogénicité vaccinale chez les usagers de drogues par injection : une revue systématique de la littérature.) |
Auteurs : | S. BARAL ; S. G. SHERMAN ; P. MILLSON ; C. BEYRER |
Type de document : | Périodique |
Année de publication : | 2007 |
Format : | 667-674 |
Note générale : |
Lancet Infectious Diseases (The), 2007, 7, (10), 667-674 |
Langues: | Français |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés INJECTION ; SYSTEME IMMUNITAIRE ; VACCINATION ; HEPATITE ; INFECTION ; VIH ; VIRUS ; TETANOSThésaurus géographique INTERNATIONAL |
Résumé : |
ENGLISH : Injection drug use is a prevalent global phenomenon; one not bound by a country's level of development or geographical location. Injection drug users (IDUs) are at high risk for a variety of parenterally acquired and transmitted infections. Licensed vaccines are available for some of these infectious diseases, such as tetanus, influenza, and hepatitis A and B viruses; however, there have been conflicting reports as to their immunogenicity in IDUs. We summarise the lessons learned from studies evaluating the immunogenicity of vaccination strategies in IDUs. A common theme across these diseases is that although there is a tendency towards decreased antibody responses after immunisation, there is no conclusive evidence linking these observations to a decrease in clinical protection from infection. There is a clear need for definitive studies of vaccination strategies in IDUs; however, a synthesis of the available published evidence suggests that immunisation does result in effective clinical protection from disease in this population. The inclusion of IDUs as a high-risk study population in future trials evaluating HIV and hepatitis C virus vaccines will help to assess the immunogenicity of candidate vaccines against parenteral exposure, and also to evaluate the efficacy of candidates as promising antigens become available. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Revue de la littérature / Literature review |
Refs biblio. : | 114 |
Affiliation : |
Center for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD 21205. Email : sbaral@jhsph.edu Etats-Unis. United States. |
Numéro Toxibase : | 1302316 |
Centre Emetteur : | 13 OFDT |
Cote : | A03446 |
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