| Titre : | Meta-regression of hepatitis C virus infection in relation to time since onset of illicit drug injection: the influence of time and place (2008) |
| Auteurs : | H. HAGAN ; E. R. POUGET ; D. C. DES JARLAIS ; C. LELUTIU-WEINBERGER |
| Type de document : | Article : Périodique |
| Dans : | American Journal of Epidemiology (Vol.168, n°10, November 15, 2008) |
| Article en page(s) : | 1099-1109 |
| Langues: | Anglais |
| Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
| Mots-clés : |
Thésaurus TOXIBASE HEPATITE ; INFECTION ; INJECTION ; REDUCTION DES RISQUES ET DES DOMMAGES ; VIH ; PREVALENCE ; MODELE ; FACTEUR DE RISQUE |
| Résumé : | The authors examined the relation between time since onset of illicit drug injection (time at risk) and rates of hepatitis C virus (HCV) infection by using meta-regression. In 72 prevalence studies, median time since onset of injection was 7.24 years and median prevalence was 66.02%. The model showed statistically significant linear and quadratic effects of time at risk on HCV prevalence and significantly higher prevalence in developing and transitional countries and in earlier samples (1985-1995). In developed countries post-1995, mean fitted prevalence was 32.02% (95% confidence interval: 25.31, 39.58) at 1 year of injection and 53.01% (95% confidence interval: 40.69, 65.09) at 5 years. In developing/transitional countries post-1995, mean fitted HCV prevalence was 59.13% (95% confidence interval: 30.39, 82.74) at 1 year of injection. In 10 incidence studies, median time at risk was 5.29 years and median cumulative HCV incidence was 20.69%. Mean fitted cumulative incidence was 27.63% (95% confidence interval: 16.92, 41.70) at 1 year of drug injection. The authors concluded that time to HCV infection in developed countries has lengthened. More rapid onset of HCV infection in drug injectors in developing/transitional countries resembles an earlier era of the HCV epidemic in other regions. (Author' s abstract) |
| Domaine : | Drogues illicites / Illicit drugs |
| Sous-type de document : | Méta-analyse / Meta-analysis |
| Refs biblio. : | 94 |
| Affiliation : | Center for Drug Use and HIV Research, National Development and Research Institutes (NDRI), New York, NY |
| Centre Emetteur : | 13 OFDT |
| Cote : | A03808 |
| Lien : | http://dx.doi.org/10.1093/aje/kwn237 |
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