| Titre : | Preference for buprenorphine/naloxone and buprenorphine among patients receiving buprenorphine maintenance therapy in France: a prospective, multicenter study (2010) |
| Auteurs : | J. P. DAULOUEDE ; Y. CAER ; P. GALLAND ; P. VILLEGER ; E. BRUNELLE ; J. BACHELLIER ; PIQUET J. M. ; J. HARBONNIER ; Y. LEGLISE ; P. COURTY |
| Type de document : | Article : Périodique |
| Dans : | Journal of Substance Abuse Treatment (Vol.38, n°1, January 2010) |
| Article en page(s) : | 83-89 |
| Note générale : |
Journal of Substance Abuse Treatment, 2010, 38, (1), 83-89 |
| Langues: | Français |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus mots-clés SUBSTITUTION ; PREFERENCE ; TRAITEMENT DE MAINTENANCE ; SATISFACTION ; BUPRENORPHINE ; NALOXONE ; ETUDE PROSPECTIVEThésaurus géographique FRANCE |
| Résumé : |
ENGLISH : Maintenance treatment with buprenorphine tablets (Subutex) has been associated with reductions in heroin use; however, concerns for intravenous misuse exist. A buprenorphine/naloxone formulation (Suboxone) was designed to reduce this misuse risk while retaining buprenorphine's efficacy and safety. This prospective, open-label, multicenter trial compared preferences for buprenorphine and buprenorphine/naloxone in 53 opioid-dependent patients stabilized on buprenorphine. Buprenorphine was first administered at the patient's current dose (Days 1-2), followed by a direct switch to buprenorphine/naloxone (Days 3-5). Global satisfaction rates were high and similar between buprenorphine and buprenorphine/naloxone; however, patients preferred the tablet taste, size, and sublingual dissolution time of buprenorphine/naloxone. At the end of the study, 54% of patients preferred buprenorphine/naloxone, 31% preferred buprenorphine, and 15% had no preference; most patients (71%) wished to continue treatment with buprenorphine/naloxone. This study did not identify any impediments to a direct buprenorphine-to-buprenorphine/naloxone switch and revealed some characteristics that may facilitate treatment with buprenorphine/naloxone. (Author' s abstract) |
| Domaine : | Drogues illicites / Illicit drugs |
| Affiliation : |
Centre Bizia, Bayonne. Email : jean-pierre.daulouede@wanadoo.fr France. France. |
| Centre Emetteur : | 13 OFDT |
| Cote : | Abonnement |
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