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Failure of reversal of cardiovascular responses of clonidine by centrally administered naloxone in anaesthetised rats
(Echec du renversement des réponses cardiovasculaires de la clonidine par la naloxone administrée par vois centrale chez des rats anesthésiés.)
Auteur(s) :
R. K. SRIVASTAVA ;
KAUR A. H.
Refs biblio. :
16
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Indian Journal of Experimental Biology, 1989, 27, 628-630
Résumé :
FRANÇAIS :
L'injection de naloxone dans le ventricule latéral n'altère pas les effets hypotenseur et bradycardisant de la clonidine chez des rats normaux ou hypertendus, qu'ils soient ou non dépendants à la morphine.
ENGLISH :
Central effects of naloxone on the cardiovascular responses of centrally administered clonidine were studied in anaesthetised normotensive, renal DOCA-salt hypertensive and morphine dependent rats. Clonidine (5 microgr./ ICV) produced significant decrease in blood pressure and heart rate in all the groups of rats in a dose dependent manner. Naloxone (2 microgr./ICV) failed to reverse the responses of clonidine in all the rats groups. In morphine dependent normotensive and morphine dependent renal DOCA-salt hypertensive rats, the responses of clonidine were further enhanced in the presence of naloxone. Our observations clearly indicate that clonidine does not influence endogenous opioid system for producing cardiovascular effects. (Author's abstract)
L'injection de naloxone dans le ventricule latéral n'altère pas les effets hypotenseur et bradycardisant de la clonidine chez des rats normaux ou hypertendus, qu'ils soient ou non dépendants à la morphine.
ENGLISH :
Central effects of naloxone on the cardiovascular responses of centrally administered clonidine were studied in anaesthetised normotensive, renal DOCA-salt hypertensive and morphine dependent rats. Clonidine (5 microgr./ ICV) produced significant decrease in blood pressure and heart rate in all the groups of rats in a dose dependent manner. Naloxone (2 microgr./ICV) failed to reverse the responses of clonidine in all the rats groups. In morphine dependent normotensive and morphine dependent renal DOCA-salt hypertensive rats, the responses of clonidine were further enhanced in the presence of naloxone. Our observations clearly indicate that clonidine does not influence endogenous opioid system for producing cardiovascular effects. (Author's abstract)
Affiliation :
Dept Pharmacol., Med. Coll., Rohtak 124001
Inde. India.
Inde. India.
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