Titre : | Naloxone induces miosis in normal subjects (1990) |
Titre traduit : | (La naloxone induit un myosis chez le sujet normal) |
Auteurs : | N. LOIMER ; R. SCHMID ; J. GRUNBERGER ; L. LINZMAYER |
Type de document : | Article : Périodique |
Dans : | Psychopharmacology (Vol.101, n°2, June 1990) |
Article en page(s) : | 282-283 |
Langues: | Anglais |
Discipline : | PAT (Pathologie organique / Organic pathology) |
Mots-clés : |
Thésaurus mots-clés ANTAGONISTE ; NALOXONE ; ENDORPHINES ; OPIACES ; RECEPTEUR ; OEIL |
Résumé : |
FRANÇAIS :
La naloxone, un antagoniste opiacé pur, induit contrairement à l'opinion généralement admise un myosis serré chez le sujet sain, non opio-dépendant. Ceci peut être la conséquence d'un effet agoniste partiel ou d'une libération locale d'endorphines consécutive à la fixation de la naloxone sur les récepteurs spécifiques. ENGLISH: In a placebo-controlled trial, pupillary constriction was measured in healthy non-addicted subjects and in opiate addicts by using static computer-assisted pupillometry. In contrast to earlier reports, a clear-cut pupillary constriction was observed in healthy persons after a single intravenous injection of 0, 4 mg naloxone. No significant changes of pupillary size were recorded in the same subjects after the administration of a placebo. In methadone-maintained subjects, the IV administration of 0, 4 mg naloxone caused a significant pupillary dilatation. From these data it can be concluded that naloxone seems to have a central pharmacological action not only in opiate addicts, but also in healthy persons. This is demonstrable by studying the miotic response. (Author's abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 7 |
Affiliation : |
Psychiat. Univ. Klin. Wien, Waehringer Guertel 18-20, 1090 Vienna Autriche. Austria. |
Numéro Toxibase : | 301386 |
Centre Emetteur : | 03 Didro |
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