Historique
Périodique
Reversible effects of acute and long-term administration of delta-9-tetrahydrocannabinol (THC) on memory in the rat
(Effets réversibles sur la mémoire du rat de l'administration unique et de l'administration répétée de delta-9-tétrahydrocannabinol)
Auteur(s) :
E. M. NAKAMURA ;
E. A. DA SILVA ;
CONCILIO G. V. ;
D. A. WILKINSON ;
J. MASUR
Refs biblio. :
40
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1991, 28, 167-175
Résumé :
FRANÇAIS :
La méthode du "labyrinthe" à 8 sorties permet d'étudier la mémoire du rat après injection de delta-9-tétrahydrocannabinol (THC). Une dose unique de 1, 5 mg / kg affecte les performances du rat, mais ces effets disparaissent après 1 heure. L'administration répétée et régulière de THC (5mg / kg) a des effets significatifs réversibles après sevrage prolongé. Le THC agirait au niveau de l'hippocampe.
ENGLISH :
A study was designed to develop a measure of both acute and chronic effects of THC administration on memory in the rat. The results provided evidence that both acute and chronic administration of THC affected working-memory in the radial arm maze test, although it did not interfere with the general cues of the task (reference memory). Chronic drug effects on memory were reversible after prolonged abstinence. Thus, the 8-arm radial maze task proved to be a useful measure of THC effects on memory and could be further used to investigate more thoroughly the mechanisms involved in such drug effects. In addition, since hippocampal formation is involved in learning and memory processes, it was hypothesized that THC effects on memory could be mediated by a hippocampal dysfunction.
La méthode du "labyrinthe" à 8 sorties permet d'étudier la mémoire du rat après injection de delta-9-tétrahydrocannabinol (THC). Une dose unique de 1, 5 mg / kg affecte les performances du rat, mais ces effets disparaissent après 1 heure. L'administration répétée et régulière de THC (5mg / kg) a des effets significatifs réversibles après sevrage prolongé. Le THC agirait au niveau de l'hippocampe.
ENGLISH :
A study was designed to develop a measure of both acute and chronic effects of THC administration on memory in the rat. The results provided evidence that both acute and chronic administration of THC affected working-memory in the radial arm maze test, although it did not interfere with the general cues of the task (reference memory). Chronic drug effects on memory were reversible after prolonged abstinence. Thus, the 8-arm radial maze task proved to be a useful measure of THC effects on memory and could be further used to investigate more thoroughly the mechanisms involved in such drug effects. In addition, since hippocampal formation is involved in learning and memory processes, it was hypothesized that THC effects on memory could be mediated by a hippocampal dysfunction.
Affiliation :
Dept Psicobiol., Escol. Paulista Med., Rua Botucatu 862, 1 andar, Caixa Postal 20399, CEP 04023 Sao Paulo
Brésil. Brazil.
Brésil. Brazil.
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