Historique
Périodique
Animal models for assessing drugs of abuse
(Modèle animal pour l'évaluation du pouvoir de dépendance des drogues)
Auteur(s) :
BRADY, J. V.
Année :
1991
Langue(s) :
Anglais
ISBN :
0149-7634
Refs biblio. :
81
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
DEPENDANCE
;
ACCOUTUMANCE
;
MILIEU SOCIOCULTUREL
;
CONDITIONNEMENT
;
MODELE ANIMAL
Note générale :
Neuroscience and Biobehavioral Reviews, 1991, 15, 35-43
Résumé :
FRANÇAIS :
L'étude de la dépendance sur modèle animal est fondée sur la mise en évidence d'un pouvoir de renforcement positif ou négatif, fonction de paramètres biochimiques, toxicologiques, pharmacologiques, comportementaux. Les auteurs étudient ce pouvoir pour diverses substances : dépresseurs, PCP, THC et proposent une définition revue des notions de dépendance et de tolérance.
ENGLISH :
There are now several converging lines of evidence that testify to the reliability and broad generality of observations concerning drug abuse liability in humans based upon animal laboratory models. The most important point of contact that characterizes the interaction between such animal assessment models and the human drug abuse arena is the demonstrated relationship between the biochemical/pharmacological/toxic properties of drugs on the one hand, and their environmental/behavioral stimulus functions on the other. As a result of these developments in animal model research technology and the consequent advances in knowledge of drug action, an operational basis has been provided for redefining the bewildering range of phenomena and experiential pseudo-phenomena loosely identify with such terms as "addiction", "dependence" and "abuse". (Extract from author's abstract)
L'étude de la dépendance sur modèle animal est fondée sur la mise en évidence d'un pouvoir de renforcement positif ou négatif, fonction de paramètres biochimiques, toxicologiques, pharmacologiques, comportementaux. Les auteurs étudient ce pouvoir pour diverses substances : dépresseurs, PCP, THC et proposent une définition revue des notions de dépendance et de tolérance.
ENGLISH :
There are now several converging lines of evidence that testify to the reliability and broad generality of observations concerning drug abuse liability in humans based upon animal laboratory models. The most important point of contact that characterizes the interaction between such animal assessment models and the human drug abuse arena is the demonstrated relationship between the biochemical/pharmacological/toxic properties of drugs on the one hand, and their environmental/behavioral stimulus functions on the other. As a result of these developments in animal model research technology and the consequent advances in knowledge of drug action, an operational basis has been provided for redefining the bewildering range of phenomena and experiential pseudo-phenomena loosely identify with such terms as "addiction", "dependence" and "abuse". (Extract from author's abstract)
Affiliation :
Div. Behavioral Biology, Traylor Bldg, Johns Hopkins Univ., Sch. Med, 720 Rutland ave, Baltimore, MD 21205
Etats-Unis. United States.
Etats-Unis. United States.