Historique
Périodique
Effects of ethanol and toluene on fixed-radio performance in short sleep and long sleep mice
(Effets de l'éthanol et du toluène sur les performances de fixed-ratio chez des souris de lignée différente)
Auteur(s) :
BALSTER, R. L. ;
WILEY, J. L. ;
TOKARZ M.E. ;
KNISELY J.S.
Année :
1992
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
62
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1992, 31, 65-75
Résumé :
FRANÇAIS :
Des souches de souris LS et SS, préconditionnées, montrent une sensibilité différente à l'alcool et au toluène. Le tolène diminue de façon plus importante la réponse comportementale, mesurée par le test du fixed-ratio.
ENGLISH :
This study examined the effects of ethanol (EtOH) and toluene on fixed-ratio (FR) responding in mice selectively bred for sensitivity to the effects of EtOH on sleep time. Although the more sensitive long sleep (LS) mice showed greater EtOH-induced impairment in a motor performance task than did the less sensitive short sleep (SS) mice, changes in FR performance in the two lines did not differ in response to EtOH, regardless of route (oral or intraperitoneal) or time (40 vs, 60 min pre-session) of administration. These results emphazise the importance of considering task variables in determination of the behavior of different genotypes. In contrast to results with EtOH, the volatile inhalant toluene produced different effects on FR responding in the selected lines, with SS mice being more sensitive than LS mice. (Author's abstract).
Des souches de souris LS et SS, préconditionnées, montrent une sensibilité différente à l'alcool et au toluène. Le tolène diminue de façon plus importante la réponse comportementale, mesurée par le test du fixed-ratio.
ENGLISH :
This study examined the effects of ethanol (EtOH) and toluene on fixed-ratio (FR) responding in mice selectively bred for sensitivity to the effects of EtOH on sleep time. Although the more sensitive long sleep (LS) mice showed greater EtOH-induced impairment in a motor performance task than did the less sensitive short sleep (SS) mice, changes in FR performance in the two lines did not differ in response to EtOH, regardless of route (oral or intraperitoneal) or time (40 vs, 60 min pre-session) of administration. These results emphazise the importance of considering task variables in determination of the behavior of different genotypes. In contrast to results with EtOH, the volatile inhalant toluene produced different effects on FR responding in the selected lines, with SS mice being more sensitive than LS mice. (Author's abstract).
Affiliation :
Dept Pharmacol. Toxicol., Virginia Commonw. Univ., Richmond, VA 23298-0613
Etats-Unis. United States.
Etats-Unis. United States.