Titre : | Behavioral pharmacology of tandospirone in baboons : chronic administration and withdrawal, self-injection and drug discrimination |
Titre traduit : | (Pharmacologie de la tandospirone chez les baboins : administration chronique, sevrage, auto-injection et discriminaiton) |
Auteurs : | SANNERUD A. ; N. A. ATOR ; R. R. GRIFFITHS |
Type de document : | Périodique |
Année de publication : | 1993 |
ISBN/ISSN/EAN : | 0376-8716 |
Note générale : |
Drug and Alcohol Dependence ,1993, 32, 195-208 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés ANXIOLYTIQUES ; POTENTIEL ADDICTIF ; AUTOADMINISTRATION ; ANIMAL |
Résumé : |
FRANÇAIS : La tandospirone, nouvel anxiolytique, agit sur les sites de la 5HT. Le mode d'action serait différent de celui des barbituriques et des benzodiazépines, et le pouvoir toxicomanogène plus faible. ENGLISH : The behavioral pharmacology of tandospirone (SM 3997), a novel anxiolytic/antidepressant pyrimidinylpiperazine compound with selective pharmacological effects at he 5-HT binding site, was investigated in baboons. Animals administered 50 mg/kg/day i.g. tandospirone, showed few behavioral changes which decreased over 2 weeks. Substitution of vehicle for tandopirone after 7 weeks produced time-limited suppression of food intake, suggesting a mild withdrawal syndrome. Under an i.v. self -injection procedure, tandospirone did not maintain responding greater than vehicle, although cocaine and triazolam did. Under a drug discrimination procedure, tandospirone did not occasion drug-appropriate responding in baboons trained to descriminate lorazepam or pentobarbital and buspirone did not occasion drug-appropriate responding in the pentobarbital-trainig group. Tandospirone's profile of effects differs from those for barbiturates and benzodiazepines and suggest low abuse liability. (From author's abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 47 |
Affiliation : |
J Hopkins Univ. Sch. Med. , BBRC-Suite 3000, 5510 Nath. Shock Dr. , Baltimore MD. 21224 Etats-Unis. United States. |
Numéro Toxibase : | 801139 |
Centre Emetteur : | 08 CAS Strasbourg |
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