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Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence
(Trouble de la personnalité antisocial en tant que facteur pronostique d'un traitement pharmacologique de la dépendance à la cocaïne)
Auteur(s) :
J. LEAL ;
D. ZIEDONIS ;
T. KOSTEN
Refs biblio. :
21
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
COCAINE
;
DEPENDANCE
;
TRAITEMENT
;
PSYCHIATRIE
;
PATHOLOGIE
;
PERSONNALITE
;
PRONOSTIC
Note générale :
Drug and Alcohol Dependence, 1994, 35, 31-35
Résumé :
FRANÇAIS :
Un trouble de la personnalité antisocial est un facteur de risque d'échec d'un traitement de la dépendance à la cocaïne par la méthadone.
ENGLISH :
Pharmacotherapy response was compared in 94 cocaine-abusing methadone patients with (n=75) and without (n=19) antisocial personality disorder (ASP), in a 12-week, randomized, double-bind trial using desipramine 150 mg daily (n=30), amantadine 300 mg daily (n=33), and placebo (n=31). Retention was lower for the ASP group (ASP 9,6 weeks vs. non-ASP 11.2 weeks). During the first 2 weeks, there was no significant difference in the percentage of cocaine-free urines between the ASP vs. non-ASP patients (9% vs. 18%), but during the last 2 weeks, the non-ASP patients showed a significantly greater percentage of cocaine-free urines (30% vs. 7%). Placebo-treated patients in both groups demonstrated no significant difference in their urine toxicologies comparing the first to the last two weeks of treatment. However, the percentage of cocaine-free urines increased from 15% to 32% in medicated non-ASP-patients, but showed no change in medicated ASP patients. Thus, antisocial personality disorder was a poor prognostic factor for treatment retention and continued cocaine abuse, and medication did not improve treatment outcome for the ASP patients, but did for the non-ASP patients.
Un trouble de la personnalité antisocial est un facteur de risque d'échec d'un traitement de la dépendance à la cocaïne par la méthadone.
ENGLISH :
Pharmacotherapy response was compared in 94 cocaine-abusing methadone patients with (n=75) and without (n=19) antisocial personality disorder (ASP), in a 12-week, randomized, double-bind trial using desipramine 150 mg daily (n=30), amantadine 300 mg daily (n=33), and placebo (n=31). Retention was lower for the ASP group (ASP 9,6 weeks vs. non-ASP 11.2 weeks). During the first 2 weeks, there was no significant difference in the percentage of cocaine-free urines between the ASP vs. non-ASP patients (9% vs. 18%), but during the last 2 weeks, the non-ASP patients showed a significantly greater percentage of cocaine-free urines (30% vs. 7%). Placebo-treated patients in both groups demonstrated no significant difference in their urine toxicologies comparing the first to the last two weeks of treatment. However, the percentage of cocaine-free urines increased from 15% to 32% in medicated non-ASP-patients, but showed no change in medicated ASP patients. Thus, antisocial personality disorder was a poor prognostic factor for treatment retention and continued cocaine abuse, and medication did not improve treatment outcome for the ASP patients, but did for the non-ASP patients.
Affiliation :
Div. Subst. Ab., Dept Psychiatr., Yale Univ. Sch. Med., Yale
Etats-Unis. United States.
Etats-Unis. United States.
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