Titre : | Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence |
Titre traduit : | (Trouble de la personnalité antisocial en tant que facteur pronostique d'un traitement pharmacologique de la dépendance à la cocaïne) |
Auteurs : | J. LEAL ; D. ZIEDONIS ; T. KOSTEN |
Type de document : | Périodique |
Année de publication : | 1994 |
ISBN/ISSN/EAN : | 0376-8716 |
Note générale : |
Drug and Alcohol Dependence, 1994, 35, 31-35 |
Langues: | Anglais |
Discipline : | PSY (Psychopathologie / Psychopathology) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; DEPENDANCE ; TRAITEMENT ; PSYCHIATRIE ; PATHOLOGIE ; PERSONNALITE ; PRONOSTIC |
Résumé : |
FRANÇAIS : Un trouble de la personnalité antisocial est un facteur de risque d'échec d'un traitement de la dépendance à la cocaïne par la méthadone. ENGLISH : Pharmacotherapy response was compared in 94 cocaine-abusing methadone patients with (n=75) and without (n=19) antisocial personality disorder (ASP), in a 12-week, randomized, double-bind trial using desipramine 150 mg daily (n=30), amantadine 300 mg daily (n=33), and placebo (n=31). Retention was lower for the ASP group (ASP 9,6 weeks vs. non-ASP 11.2 weeks). During the first 2 weeks, there was no significant difference in the percentage of cocaine-free urines between the ASP vs. non-ASP patients (9% vs. 18%), but during the last 2 weeks, the non-ASP patients showed a significantly greater percentage of cocaine-free urines (30% vs. 7%). Placebo-treated patients in both groups demonstrated no significant difference in their urine toxicologies comparing the first to the last two weeks of treatment. However, the percentage of cocaine-free urines increased from 15% to 32% in medicated non-ASP-patients, but showed no change in medicated ASP patients. Thus, antisocial personality disorder was a poor prognostic factor for treatment retention and continued cocaine abuse, and medication did not improve treatment outcome for the ASP patients, but did for the non-ASP patients. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 21 |
Affiliation : |
Div. Subst. Ab., Dept Psychiatr., Yale Univ. Sch. Med., Yale Etats-Unis. United States. |
Numéro Toxibase : | 801347 |
Centre Emetteur : | 08 CAS Strasbourg |
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