Titre : | Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients (2000) |
Titre traduit : | (Disponibilité des transporteurs centraux de la serotonine chez des cocaïnomanes abstinents) |
Auteurs : | L. K. JACOBSEN ; J. K. STALEY ; MALISON R. T. ; S. S. ZOGHBI ; SEIBYL J. P. ; T. R. KOSTEN ; INNIS R. B. |
Type de document : | Article : Périodique |
Dans : | American Journal of Psychiatry (Vol.157, n°7, July 2000) |
Article en page(s) : | 1134-1140 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; NEUROBIOLOGIE ; SEROTONINE ; DOPAMINE ; ABSTINENCE ; NEUROTRANSMETTEURS ; MECANISME D'ACTION |
Résumé : | Objective: Recent work has underscored the role of serotonergic neurotransmission in chronic neural adaptations to cocaine dependence. The authors tested for evidence of serotonergic dysfunction during acute abstinence from cocaine, a period of high risk for relapse in cocaine dependence. Method: Binding availability of dopamine transporters and serotonin transporters was measured in 15 cocaine-dependent subjects during acute abstinence and in 37 healthy comparison subjects by using [123]b-CIT and single photon emission computed tomography. Results: Significant increases in diencephalic and brainstem serotonin transporter binding (16.7% and 31.6%, respectively) were observed in cocaine-dependent subjects. Brainstem serotonin transporter binding was significantly inversely correlated with age across diagnostic groups. Conclusions: These findings provide futher evidence of serotonergic dysfunction during acute abstinence from chronic cocaine use. Age-related decline in brainstem serotonin transporter binding may underlie the poor response to selective serotonin reuptake inhibitor antidepressants seen in some elderly depressed patients. (Author's abstract.) |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 59 |
Affiliation : |
Psychiatry 116A, 950 Campbell ave., West Haven, CT 06516 leslie.jacobsenyale.edu Etats-Unis. United States. |
Numéro Toxibase : | 102343 |
Centre Emetteur : | 01 Pey Berland |
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