Historique
Article de Périodique
Agony and ecstasy: a review of MDMA effects and toxicity (2000)
(Agonie et ecstasy : une revue des effets et de la toxicité du MDMA)
Auteur(s) :
BURGESS C. ;
O'DONOHOE A. ;
M. GILL
Article en page(s) :
287-294
Sous-type de document :
Revue de la littérature / Literature review
Refs biblio. :
61
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
MDMA-ECSTASY
;
TOXICITE
;
EFFET SECONDAIRE
;
PATHOLOGIE ORGANIQUE
;
PSYCHOPATHOLOGIE
;
GENETIQUE
Résumé :
Background - Ecstasy is a recreational drug with an anecdotal reputation for safety. However, reports of adverse effects and fatalities have increased in the medical and popular press. Method - Literature search and review. Results - Acute Ecstasy toxicity does not appear to be due to overdose and cannot be solely attributed to the nature of the usual ambient environment. Adverse effects include hyperthermia, seizures, cardiac arrhythmias, hepatotoxicity, hyponatraemia and many psychiatric disorders. Ecstasy causes serotonergic neurotoxicity in the brains of animals at doses close to those used by humans, but its long-term effect on the human brain is unknown. Conclusion - Ecstasy toxicity should be considered in the differential diagnosis of a variety of medical and psychiatric conditions. Given its popularity, both the acute and the potential long-term effects are a cause for concern. (Author' s abstract)
Affiliation :
Dept Psychiat., Trinity Hlth Sci. Ctre, St-James's Hosp., Dublin 8
Irlande. Ireland.
Irlande. Ireland.