Titre : | The promise of opioid receptor antagonist drugs in the treatment of neuropsychiatric disorders |
Titre traduit : | (L'action prometteuse des antagonistes opioïdes dans le traitement des troubles neuropsychiatriques.) |
Auteurs : | J. A. DELTITO ; I. MAREMMANI |
Type de document : | Périodique |
Année de publication : | 2001 |
Format : | 7-11 |
Note générale : |
Heroin Addiction and Related Clinical Problems, 2001, 3, (1), 7-11
|
Langues: | Anglais |
Discipline : | PSY (Psychopathologie / Psychopathology) |
Mots-clés : |
Thésaurus mots-clés NALOXONE ; OPIOIDES ; ANTAGONISTE ; NEUROPSYCHIATRIE ; PSYCHOPATHOLOGIE ; USAGE THERAPEUTIQUE ; EFFICACITE |
Résumé : | The endogenous opioid system, either directly or through its influence on other neurotransmitter systems, has far-reaching effects on normal as well as abnormal (maladaptive) behaviours, thoughts and mood states. Altering this system through the use of an opioid antagonist medication may not only be useful in treating recognized psychiatric illnesses, but may also prove to be valuable in elucidating psychophysiological abnormalities that could contribute to the foundation of these disorders. Opioid Antagonists Naltrexone and Naloxone have been used in substance abuse illnesses (narcotics, alcohol, tobacco) but have also been administered in variety of psychiatric conditions, including Anoxeria Nervosa, Bulimia, Schizophrenia, Self-injurious Behaviour (as part of Borderline Personality Disorder and other conditions), Austim, Obsessive-Compulsove Disorder, Tourette's Disease and Trichotillomania. A review of the clinical effectiveness of Naltrexone and Naloxone reveals many situations that call for a therapeutic trial on opioid antagonists in these conditions, despite the lack of a robust database demonstrating the clear efficacy of these medications in the global resolution of any of these conditions. A psychopathological reconceptualization of the conditions mentioned above, focusing on symptoms rather than syndromes, may prove to be a great clinical value. (Author' s abstract) |
Domaine : | Drogues illicites / Illicit drugs |
Affiliation : |
7 Thomes St., Rowayton, CT 06853 Etats-Unis. United States. |
Numéro Toxibase : | 205713 |
Centre Emetteur : | 02 Coordonnateur |
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