Titre : | The effects of chronic morphine on behavior reinforced by several opioids or by cocaine in rhesus monkeys |
Titre traduit : | (Effets de l'administration chronique de morphine sur le renforcement du comportement par les opiacés ou la cocaïne chez des singes rhésus) |
Auteurs : | G. WINGER ; J. H. WOODS |
Type de document : | Périodique |
Année de publication : | 2001 |
Format : | 181-189 |
Note générale : |
Drug and Alcohol Dependence, 2001, 62, (3), 181-189
|
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés MORPHINE ; OPIACES ; COCAINE ; TOLERANCE ; AUTOADMINISTRATION ; RENFORCEMENT ; MODELE ANIMAL |
Résumé : | The reinforcing effects of intravenously delivered cocaine, alfentanil, morphine, heroin, nalbuphine, or buprenorphine were evaluated in four rhesus monkeys before, during, and after daily administration of 3.2 mg/kg morphine. Morphine was given 21 h prior to measures of the reinforcing effects of each of the drugs. No changes in the potency of cocaine or the high efficacy mu agonist alfentanil were detectable during the period of chronic morphine administration. Small (1/2-1) log unit decreases in the reinforcing potency of intermediate efficacy mu agonists morphine and heroin occurred during chronic morphine administration. Larger decreases in both the potency and effectiveness of low-efficacy mu agonists nalbuphine and buprenorphine developed during this time. These data suggest that the amount of tolerance that develops to the reinforcing effects of opioids depends on the efficacy of the drugs used to maintain responding. (Author's abstract.) |
Domaine : | Autres substances / Other substances ; Drogues illicites / Illicit drugs |
Affiliation : |
Dept. Pharmacol., Univ. MI, 1501 W. Medical Ctr. Drive, Ann Arbor, MI 48109 Etats-Unis. United States. |
Numéro Toxibase : | 803661 |
Centre Emetteur : | 08 CAS Strasbourg |
Exemplaires
Disponibilité |
---|
aucun exemplaire |
Accueil