|
Titre :
|
Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder : two randomised controlled trials
|
|
Titre original:
|
(Méthadone et amantadine pour le traitement des héroïnomanes présentant ou ne présentant pas d'usage problématique de cocaïne : deux essais contrôlés randomisés)
|
|
Auteurs :
|
J. PEREZ DE LOS COBOS ;
P. DURO ;
J. TRUJOLS ;
A. TEJERO ;
F. BATLLE ;
E. RIBALTA ;
M. CASAS
|
|
Type de document :
|
Périodique
|
|
Année de publication :
|
2001
|
|
Format :
|
187-195
|
|
Note générale :
|
Drug and Alcohol Dependence, 2001, 63, (2), 187-195
|
|
Langues:
|
Anglais
|
|
Discipline :
|
TRA (Traitement et prise en charge / Treatment and care)
|
|
Mots-clés :
|
Thésaurus TOXIBASE
METHADONE
;
COCAINE
;
HEROINE
;
POLYCONSOMMATION
;
SEVRAGE
;
ANTIPARKINSONIENS
;
TRAITEMENT
;
ESSAI THERAPEUTIQUE
|
|
Résumé :
|
The efficacy of methadone tapering plus amantadine to detoxify heroin-dependent patients with or without an active cocaine use disorder was studied in a closed unit with two successive double-blind, placebo-controlled, 14-day trials. In the first trial, 40 heroin-dependent inpatients with an active cocaine use disorder were treated using methadone tapering, as well as amantadine (200-300 mg per day) or placebo. In the second trial, 40 heroin-dependent inpatients without an active cocaine use disorder received the same treatment. In both the trials, arnantadine did not have a statistically significant effect on treatment completion, nor did it contribute, in completers, to a more rapid reduction in craving and opiate withdrawal. In the first trial, women were six times more likely than men to be non-completers, and on the last day of treatment, the first trial's completers and non-completers presented a comparable clinical state. (Author's abstract.)
|
|
Domaine :
|
Autres substances / Other substances ; Drogues illicites / Illicit drugs
|
|
Affiliation :
|
Dept. Psychiatr., Hospital Santa Creu i Sant Pau, Barcelona Auton. Univ. Sch. Med., Sant Antoni Ma Claret, 167, 08025 Barcelona
Espagne. Spain.
|
|
Numéro Toxibase :
|
803687
|
|
Centre Emetteur :
|
08 CAS Strasbourg
|
Accueil
