| Titre : | Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder : two randomised controlled trials |
| Titre original: | (Méthadone et amantadine pour le traitement des héroïnomanes présentant ou ne présentant pas d'usage problématique de cocaïne : deux essais contrôlés randomisés) |
| Auteurs : | J. PEREZ DE LOS COBOS ; P. DURO ; J. TRUJOLS ; A. TEJERO ; F. BATLLE ; E. RIBALTA ; M. CASAS |
| Type de document : | Périodique |
| Année de publication : | 2001 |
| Format : | 187-195 |
| Note générale : |
Drug and Alcohol Dependence, 2001, 63, (2), 187-195
|
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus TOXIBASE METHADONE ; COCAINE ; HEROINE ; POLYCONSOMMATION ; SEVRAGE ; ANTIPARKINSONIENS ; TRAITEMENT ; ESSAI THERAPEUTIQUE |
| Résumé : | The efficacy of methadone tapering plus amantadine to detoxify heroin-dependent patients with or without an active cocaine use disorder was studied in a closed unit with two successive double-blind, placebo-controlled, 14-day trials. In the first trial, 40 heroin-dependent inpatients with an active cocaine use disorder were treated using methadone tapering, as well as amantadine (200-300 mg per day) or placebo. In the second trial, 40 heroin-dependent inpatients without an active cocaine use disorder received the same treatment. In both the trials, arnantadine did not have a statistically significant effect on treatment completion, nor did it contribute, in completers, to a more rapid reduction in craving and opiate withdrawal. In the first trial, women were six times more likely than men to be non-completers, and on the last day of treatment, the first trial's completers and non-completers presented a comparable clinical state. (Author's abstract.) |
| Domaine : | Autres substances / Other substances ; Drogues illicites / Illicit drugs |
| Affiliation : |
Dept. Psychiatr., Hospital Santa Creu i Sant Pau, Barcelona Auton. Univ. Sch. Med., Sant Antoni Ma Claret, 167, 08025 Barcelona Espagne. Spain. |
| Numéro Toxibase : | 803687 |
| Centre Emetteur : | 08 CAS Strasbourg |
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