Historique
Périodique
Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder : two randomised controlled trials
(Méthadone et amantadine pour le traitement des héroïnomanes présentant ou ne présentant pas d'usage problématique de cocaïne : deux essais contrôlés randomisés)
Auteur(s) :
PEREZ DE LOS COBOS, J. ;
DURO, P. ;
TRUJOLS, J. ;
TEJERO, A. ;
BATLLE, F. ;
RIBALTA, E. ;
CASAS, M.
Année :
2001
Page(s) :
187-195
Langue(s) :
Anglais
Domaine :
Autres substances / Other substances ; Drogues illicites / Illicit drugs
Thésaurus mots-clés
METHADONE
;
COCAINE
;
HEROINE
;
POLYCONSOMMATION
;
SEVRAGE
;
ANTIPARKINSONIENS
;
TRAITEMENT
;
ESSAI THERAPEUTIQUE
Note générale :
Drug and Alcohol Dependence, 2001, 63, (2), 187-195
Résumé :
The efficacy of methadone tapering plus amantadine to detoxify heroin-dependent patients with or without an active cocaine use disorder was studied in a closed unit with two successive double-blind, placebo-controlled, 14-day trials. In the first trial, 40 heroin-dependent inpatients with an active cocaine use disorder were treated using methadone tapering, as well as amantadine (200-300 mg per day) or placebo. In the second trial, 40 heroin-dependent inpatients without an active cocaine use disorder received the same treatment. In both the trials, arnantadine did not have a statistically significant effect on treatment completion, nor did it contribute, in completers, to a more rapid reduction in craving and opiate withdrawal. In the first trial, women were six times more likely than men to be non-completers, and on the last day of treatment, the first trial's completers and non-completers presented a comparable clinical state. (Author's abstract.)
Affiliation :
Dept. Psychiatr., Hospital Santa Creu i Sant Pau, Barcelona Auton. Univ. Sch. Med., Sant Antoni Ma Claret, 167, 08025 Barcelona
Espagne. Spain.
Espagne. Spain.