FRANÇAIS :
Pour déterminer si la présence de symptômes dépressifs subcliniques est liée aux réponses physiologiques et subjectives à la consommation de cocaïne fumée, on administre une dose unique de cocaïne de 0,4mg/kg à des usagers ne souffrant pas de dépression majeure. En comparant les scores de l'inventaire de dépression de Beck (Beck Depression Inventory ou BDI) et les réponses à l'administration de cocaïne, on trouve des tendances similaires. Un score de BDI bas (0-7) est associé à une réponse physiologique et subjective faible à la cocaïne et des scores élevés (8-13) sont associés à des réponses fortes atteignant un plateau et déclinant après un indice de 14. Les différences de poids et de sexes ne sont pas en cause.

ENGLISH:
The goal of this study was to examine the relationship between the presence of subclinical depressive symptoms and physiological and subjective responses to smoked cocaine in humans. Cocaine users without major depression, who participated in various inpatient studies, received a single 0.4 mg/kg of smoked cocaine. When the relationship between the Beck Depression Inventory (BDI) scores and various subjective and physiological responses to cocaine was examined, similar trends were found. Low BDI scores of 0-7 were associated with a smaller physiological and subjective cocaine response. In contrast, BDI ranges of 8-13 were associated with enhanced cocaine response which plateaued or declined in the higher (> 14) BDI group. These group differences were not explained by sex or body weight differences among groups. The implication of these results is that the presence of depressive symptoms may affect cocaine use behavior partly by being associated with an enhanced response to cocaine. (Author's abstract.)