Titre : | Two methods of community detoxification from opiates: an open-label comparison of lofexidine and buprenorphine |
Titre traduit : | (Etude comparative de deux méthodes de sevrage d'opiacés par la loféxidine et la buprénorphine) |
Auteurs : | R. WHITE ; R. ALCORN ; C. FEINMANN |
Type de document : | Périodique |
Année de publication : | 2001 |
Format : | 77-83 / tabl. ; graph. |
Note générale : |
Drug and Alcohol Dependence, 2001, 65, (1), 77-83 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; OPIACES ; CLONIDINE ; TRAITEMENT AMBULATOIRE ; SYNDROME DE SEVRAGE ; COMPARAISON ; EFFICACITE |
Résumé : |
ENGLISH : There is currently no consensus on the best approach to the management of opiate detoxification. In the current open-label study, 69 opiate-dependent individuals requesting outpatient detoxification were allocated to two different medication regimes: lofexidine and buprenorphine. Allocation was dependent on the timing of their presentation. Lofexifidine is a structural analogue of clonidine, and used widely in the UK. Buprenorphine is a partial opiate agonist with unusual pharmacological properties. Outcomes were better for the buprenorphine-receiving group (n=38). Clients receiving buprenorphine had a less severe withdrawal syndrome, and were more likely to complete their detoxification. In addition, for the buprenorphine-receiving group it was found that the withdrawal syndrome was least in those prescribed an initial dose of 4 mg. The findings and their implications are discussed. The design of the study precludes definitive conclusions regarding relative efficacy. (Author's abstract.) |
Note de contenu : | tabl. ; graph. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 31 |
Affiliation : |
St Lukes Woodside Hosp., Woodside Av., Muswell Hill, London N10 3HU Royaume-Uni. United Kingdom. |
Numéro Toxibase : | 803784 |
Centre Emetteur : | 08 CAS Strasbourg |
Exemplaires
Disponibilité |
---|
aucun exemplaire |
Accueil