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The HPA axis in cocaine use: implications for pharmacotherapy
(L'axe l'hypothalamo-hypophyso-surrénalien et l'usage de cocaïne : les implications pour le traitement médicamenteux.)
Auteur(s) :
T. WINHUSEN ;
SOMOZA E.
Article en page(s) :
105-119
Refs biblio. :
49
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Note générale :
Journal of Addictive Diseases, 2001, 20, (3), 105-119
Note de contenu :
fig.
Résumé :
ENGLISH :
The role of the hypothalamic-pituitary-adrenal (HPA) axis in cocaine use is reviewed within the context of two approaches to developing pharmacological treatments in humans: (1) reducing the reinforcing effects of cocaine and (2) reducing cocaine addict's susceptibility to stress-induced relapse. This review suggests that HPA-axis-suppressing medications are unlikely to block cocaine's reinforcing effects completely but may be useful in decreasing the frequency of use by increasing the addicted individual's resistance to stress-induced relapse. Implications for designing inpatient studies to test the safety and efficacy of candidate pharmacological agents are discussed. (Editor' s abstract)
ENGLISH :
The role of the hypothalamic-pituitary-adrenal (HPA) axis in cocaine use is reviewed within the context of two approaches to developing pharmacological treatments in humans: (1) reducing the reinforcing effects of cocaine and (2) reducing cocaine addict's susceptibility to stress-induced relapse. This review suggests that HPA-axis-suppressing medications are unlikely to block cocaine's reinforcing effects completely but may be useful in decreasing the frequency of use by increasing the addicted individual's resistance to stress-induced relapse. Implications for designing inpatient studies to test the safety and efficacy of candidate pharmacological agents are discussed. (Editor' s abstract)
Affiliation :
Cincinnati Addiction Res. Ctre, 3210 Jefferson Ave, Cincinnati, OH 45220, email: winhusen@mdru.uc.edu
Etats-Unis. United States.
Etats-Unis. United States.
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