| Titre : | The HPA axis in cocaine use: implications for pharmacotherapy |
| Titre traduit : | (L'axe l'hypothalamo-hypophyso-surrénalien et l'usage de cocaïne : les implications pour le traitement médicamenteux.) |
| Auteurs : | T. WINHUSEN ; SOMOZA E. |
| Type de document : | Périodique |
| Année de publication : | 2001 |
| Format : | 105-119 / fig. |
| Note générale : |
Journal of Addictive Diseases, 2001, 20, (3), 105-119 |
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus mots-clés COCAINE ; TRAITEMENT ; STRESS ; COMPULSION ; SYSTEME ENDOCRINIEN |
| Résumé : |
ENGLISH : The role of the hypothalamic-pituitary-adrenal (HPA) axis in cocaine use is reviewed within the context of two approaches to developing pharmacological treatments in humans: (1) reducing the reinforcing effects of cocaine and (2) reducing cocaine addict's susceptibility to stress-induced relapse. This review suggests that HPA-axis-suppressing medications are unlikely to block cocaine's reinforcing effects completely but may be useful in decreasing the frequency of use by increasing the addicted individual's resistance to stress-induced relapse. Implications for designing inpatient studies to test the safety and efficacy of candidate pharmacological agents are discussed. (Editor' s abstract) |
| Note de contenu : | fig. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 49 |
| Affiliation : |
Cincinnati Addiction Res. Ctre, 3210 Jefferson Ave, Cincinnati, OH 45220, email: winhusen@mdru.uc.edu Etats-Unis. United States. |
| Numéro Toxibase : | 205882 |
| Centre Emetteur : | 02 Coordonnateur |
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