Titre : | Time to initiating highly active antiretroviral therapy among HIV-infected injection drug users |
Titre traduit : | (Délai pour initier un traitement antiretroviral intensif - HAART - chez des usagers de drogues par injection) |
Auteurs : | D. D. CELENTANO ; N. GALAI ; SETHI A. K. ; N. G. SHAH ; STRATHDDD S. A. ; D. VLAHOV ; GALLANT J. E. |
Type de document : | Périodique |
Année de publication : | 2001 |
Format : | 1707-1715 / fig. ; tabl. |
Note générale : |
AIDS, 2001, 15, (13), 1707-1715 |
Langues: | Anglais |
Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
Mots-clés : |
Thésaurus mots-clés USAGER ; ANTIRETROVIRAUX ; VOIE INTRAVEINEUSE ; VIH ; ACCES AUX SOINS ; TRAITEMENT |
Résumé : |
ENGLISH : Objective: Studies have shown that HIV-infected injection drug users (IDUs) are less likely to receive antiretroviral therapy than non-drug users. We assess factors associated with initiating highly active antiretroviral therapy (HAART) in HIV-infected IDUs. Methods: A cohort study of IDUs carried out between 1January 1996 and 30 June 1999 at a community-based study clinic affiliated to the Johns Hopkins University, Baltimore, Maryland. The participants were a total of 528 HIV-infected IDUs eligible for HAART based on CD4+ cell count. The main outcome measure was the time from treatment eligibility to first self-reported HAART use, as defined by the international AIDS Society-USA panel (IAS-USA) guidelines. Results: By 30 June 1999, 58.5% of participants had initiated HAART, most of whom switched from mono- or dual-combination therapy to a HAART regimen. Nearly one-third of treatment-eligible IDUs never received antiretroviral therapy. Cox proportional hazards regression showed that initiating HAART was independently associated with not injecting drugs, methadone treatment among men, having health insurance and a regular source of care, lower CD4+ cell count and a history of antiretroviral therapy. Conclusions: Self-reported initiation of HAART is steadily increasing among IDUs who are eligible for treatment; however, a large proportion continues to use non-HAART regimens and many remain treatment-naive. Although both groups appear to have lower health care access and utilization, IDUs without a history of antiretroviral therapy use would have more treatment options available to them once they become engaged in HIV care. (Author' s abstract) |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 28 |
Affiliation : |
Dept Epidem., Johns Hopkins Sch. Hyg. Public Hlth, 615 N Wolfe St (E-7132), Baltimore, MD 21205 Etats-Unis. United States. |
Numéro Toxibase : | 205953 |
Centre Emetteur : | 02 Coordonnateur |
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