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A controlled trial of methadone treatment combined with directly observed isoniazid for tuberculosis prevention in injection drug users
(Essai contrôlé de traitement d'usagers de drogues injecteurs associant la méthadone et un traitement préventif de la tuberculose)
Auteur(s) :
BATKI, S. L. ;
GRUBER V. A. ;
MOON BRADLEY, J. ;
BRADLEY, M. ;
DELUCCHI, K.
Année :
2002
Page(s) :
283-293
Langue(s) :
Anglais
Refs biblio. :
59
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
METHADONE
;
ANTIBIOTIQUES
;
TUBERCULOSE
;
USAGER
;
PHARMACOTHERAPIE
;
TRAITEMENT DE MAINTENANCE
;
PREVENTION SECONDAIRE
Note générale :
Drug and Alcohol Dependence, 2002, 66, (3), 283-293
Note de contenu :
fig. ; tabl.
Résumé :
ENGLISH :
Substance abuse is associated with high risk for tuberculosis (TB) and poor adherence to medication regimens. This study compared completion rates for isoniazid (INH) preventive therapy for injection drug users (IDUs) randomly assigned to methadone treatment combined with directly observed preventive treatment (DOPT) versus those assigned to routine TB clinic referral without methadone treatment. One hundred and eleven opioid-dependent patients with latent TB were assigned to one of three 6-month treatment conditions: standard methadone treatment including substance abuse counseling combined with daily INH DOPT (n = 37); minimal methadone treatment without counseling, also combined with daily INH DOPT (n = 35); or routine care referral to TB clinic for monthly INH supplies without DOPT and without methadone treatment (n = 39). INH completion rates were 77.1% for minimal methadone and 59.5% for standard methadone, as compared with only 13.5% for routine care (P
Affiliation :
Dept. Psychiatr., State Univ. NY Upstate Med. Univ., 750 E. Adams St., Syracuse, NY 13210
Etats-Unis. United States.
Etats-Unis. United States.