Titre : | The use of Levo-Alpha-Acetylmethadol (LAAM) in Methadone patients who have not achieved heroin abstinence |
Titre traduit : | (Prescription de LAAM à des patients en traitement de maintenance à la méthadone non abstinents de l'héroïne.) |
Auteurs : | BORG L. ; A. HO ; A. WELLS ; H. JOSEPH ; P. APPEL ; D. MOODY ; M. J. KREEK |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 13-22 / graph. |
Note générale : |
Journal of Addictive Diseases, 2002, 21, (3), 13-22 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés LAAM ; ABSTINENCE ; HEROINE ; EFFICACITE ; TRAITEMENT DE MAINTENANCE ; METHADONE |
Résumé : |
ENGLISH : Levo-alpha-acetylmethadol (LAAM) pharmacotherapy was offered to twelve patients who continued illicit opioid abuse after >- eleven months in methadone maintenance treatment. After 6-8 weeks on LAAM, plasma concentrations of the norLAAM metabolite varied significantly by LAAM dosing day, plasma adrenocorticotropin (ACTH) concentrations were significantly increased compared to methadone, and two of the seven subjects remaining in LAAM treatment were free of illicit opioids and nonprescribed methadone. After one year, one of five remaining subjects was using illicit opioids, and three were using non-prescribed methadone. While subject acceptance of LAAM was high, subjects were not in a "steady-state", with evidence of ongoing illicit opioid abuse. (Author' s abstract) |
Note de contenu : | graph. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 20 |
Affiliation : |
The Rockfeller Univ., The Laboratory of the Biology of Addictive Diseases (Box 171), 1230 York Avenue, New York, NY 10021 Etats-Unis. United States. |
Numéro Toxibase : | 206349 |
Centre Emetteur : | 02 Coordonnateur |
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