Historique
Périodique
The pharmacokinetics of methadone following co-administration with a lamivudine/zidovudine combination tablet in opiate-dependent subjects
(La pharmacocinétique de la méthadone après une administration conjointe de comprimés de lamivudine et de zidovudine chez des patients dépendants des opiacés.)
Auteur(s) :
RAINEY P. M. ;
FRIEDLAND, G. H. ;
SNIDOW J. W. ;
McCANCE-KATZ, E. F. ;
MITCHELL, S. M. ;
ANDREWS, L. ;
LANE, B. ;
JATLOW P.
Année :
2002
Page(s) :
66-74
Langue(s) :
Anglais
Refs biblio. :
35
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
METHADONE
;
ANTIRETROVIRAUX
;
INTERACTION CHIMIQUE
;
PHARMACOCINETIQUE
;
DOSE-REPONSE
Note générale :
American Journal on Addictions, 2002, 11, (1), 66-74
Note de contenu :
fig. ; tabl.
Résumé :
ENGLISH :
Methadone pharmacokinetics were determined in an open-label, within subject study in 16 methadone-maintained, non-HIV-infected subjects prior to and following administration of one lamivudine 150-mg/zidovudine 300-mg combination tablet to determine whether this antiretroviral therapy alters methadone serum concentrations. No significant differences in the mean area under the serum concentration-time curve, oralclearance, oral volume of distribution, maximum serum concentration, or terminal elimination half-life were detected. These results suggest that methadone dose change is not likely to be necessary for patients treated with lamivudine/zidovudine combination pharmacotherapy. (Extract of the publication)
Affiliation :
Dep. Laboratory Medicine, Univ. Washington, PO Box 357110, Seattle, WA 98195-7110, E-mail: pmrainey@u.washington.edu
Etats-Unis. United States.
Etats-Unis. United States.