Titre : | Cognitive and motor outcomes of cocaine-exposed infants |
Titre traduit : | (Problèmes cognitifs et moteurs chez des enfants ayant subi une exposition prénatale à la cocaïne.) |
Auteurs : | L. T. SINGER ; R. ARENDT ; S. MINNES ; K. FARKAS ; SALVATOR A. ; H. L. KIRCHNER ; KLIEGMAN R. |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 1952-1960 / tabl. |
Note générale : |
Journal of the American Medical Association, 2002, 287, (15), 1952-1960 |
Langues: | Anglais |
Mots-clés : |
Thésaurus mots-clés COCAINE ; FOETUS ; EFFET SECONDAIRE ; COGNITION ; TEST ; ETUDE LONGITUDINALE ; EPIDEMIOLOGIE |
Résumé : |
ENGLISH : Maternal use of cocaine during pregnancy remains a significant public health problem, particularly in urban areas of the United States and among women of low socioeconomic status. Few longitudinal studies have examined cocaine-exposed infants, however, and findings are contradictory because of methodologic limitations. Objective: To assess the effects of prenatal cocaine exposure on child developmental outcomes. Design: Longitudinal, prospective, masked, comparison birth cohort study with recruitment in 1994-1996. Setting: Obstetric unit of a large US urban teaching hospital. Participants: Four hundred fifteen consecutively enrolled infants (218 cocaine-exposed and 197 unexposed) identified from a high-risk, low-socioeconomic status, primarily black (80%) population screened through clinical interview and urine and meconium samples for drug use. The retention rate was 94% at 2 years of age. Main Outcome Measures: The Bayley Mental and Motor Scales of Infant Development, assessed at 6.5, 12, and 24 months of corrected age. Results: Controlled for confounding variables, cocaine exposure had significant effects on cognitive development, accounting for a 6-point deficit in Bayley Mental and Motor Scales of Infant Development scores at 2 years, with cocaine-exposed children twice as likely to have significant delay (mental development index |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 45 |
Affiliation : |
Case Western Reserve Univ., Triangle Bldg, 11400 Euclid Ave, Suite 250-A, Cleveland, OH 44106 France. France. |
Numéro Toxibase : | 206180 |
Centre Emetteur : | 02 Coordonnateur |
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