Historique
Périodique
Buprenorphine dosing regime in the management of out-patient heroin withdrawal
(Adaptation des doses de buprénorphine au cours du sevrage ambulatoire d'héroïne)
Auteur(s) :
LINTZERIS, N.
Année :
2002
Page(s) :
39-45
Langue(s) :
Anglais
Refs biblio. :
29
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
BUPRENORPHINE
;
HEROINE
;
DEPENDANCE
;
TRAITEMENT DE MAINTENANCE
;
POSOLOGIE
;
ADAPTATION
Note générale :
Drug and Alcohol Review, 2002, 21, (1), 39-45
Note de contenu :
tabl. ; graph.
Résumé :
ENGLISH :
This study aimed to establish a buprenorphine regime suitable for the short-term management of out-patient heroin withdrawal using an open-label, single-group case series. Eighteen dependent injecting heroin users underwent an 8-day withdrawal episode with supervised dosing of sublingual Subutex-R tablets. Buprenorphine doses were titrated daily over a 5-day period. Fifteen subjects (83%) completed the 5-day regime, and 14 (78%) completed the 8-day withdrawal episode. The mean doses ((SD) were 6.1 (1.2) mg on day 1; 9.6 (1.7) mg on day 2; 10.1 (1.9) mg on day 3; 8.9 (2.0) mg on day 4; 4.1 (1.5) mg on day 5; and a total regime dose of 38.9 (5.8) mg. Withdrawal severity was mild, with minimal rebound upon the cessation of dosing. Five subjects reported no heroin use, and five subjects reported using on only one occasion during the 8 days. An outpatient buprenorphine regime is recommended. (Author's abstract.)
Affiliation :
54-62 Gertrude St., Fitzroy, Victoria 3065
Australie. Australia.
Australie. Australia.