Titre : | Buprenorphine dosing regime in the management of out-patient heroin withdrawal |
Titre traduit : | (Adaptation des doses de buprénorphine au cours du sevrage ambulatoire d'héroïne) |
Auteurs : | N. LINTZERIS |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 39-45 / tabl. ; graph. |
Note générale : |
Drug and Alcohol Review, 2002, 21, (1), 39-45 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; HEROINE ; DEPENDANCE ; TRAITEMENT DE MAINTENANCE ; POSOLOGIE ; ADAPTATION |
Résumé : |
ENGLISH : This study aimed to establish a buprenorphine regime suitable for the short-term management of out-patient heroin withdrawal using an open-label, single-group case series. Eighteen dependent injecting heroin users underwent an 8-day withdrawal episode with supervised dosing of sublingual Subutex-R tablets. Buprenorphine doses were titrated daily over a 5-day period. Fifteen subjects (83%) completed the 5-day regime, and 14 (78%) completed the 8-day withdrawal episode. The mean doses ((SD) were 6.1 (1.2) mg on day 1; 9.6 (1.7) mg on day 2; 10.1 (1.9) mg on day 3; 8.9 (2.0) mg on day 4; 4.1 (1.5) mg on day 5; and a total regime dose of 38.9 (5.8) mg. Withdrawal severity was mild, with minimal rebound upon the cessation of dosing. Five subjects reported no heroin use, and five subjects reported using on only one occasion during the 8 days. An outpatient buprenorphine regime is recommended. (Author's abstract.) |
Note de contenu : | tabl. ; graph. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 29 |
Affiliation : |
54-62 Gertrude St., Fitzroy, Victoria 3065 Australie. Australia. |
Numéro Toxibase : | 803900 |
Centre Emetteur : | 08 CAS Strasbourg |
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