Titre : | Retention rate and illicit opioid use during methadone maintenance interventions : a meta-analysis |
Titre traduit : | (Méta-analyse du taux de rétention et de l'usage illicite d'opiacés chez les patients en traitement de maintenance par la méthadone) |
Auteurs : | M. FARRE ; A. MAS ; M. TORRENS ; V. MORENO ; J. CAMI |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 283-290 / tabl. ; graph. |
Note générale : |
Drug and Alcohol Dependence, 2002, 65, (3), 283-290 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés OPIACES ; METHADONE ; BUPRENORPHINE ; LAAM ; TRAITEMENT DE MAINTENANCE ; COMPARAISON ; EFFICACITE ; RETENTION |
Résumé : |
ENGLISH : The efficacy of methadone maintenance in opioid addiction was assessed in terms of programme retention rate and reduction of illicit opioid use by means of a meta-analysis of randomised, controlled and double blind clinical trials. The results were compared with interventions using buprenorphine and levo-acetylmethadol (LAAM). Trials were identified from the PubMed database from 1966 to December 1999 using the major medical subject headings 'methadone' and 'randomised controlled trial'. Data for a total of 1944 opioid-dependent patients from 13 studies were analysed. Sixty-four percent of patients received methadone, administered either as fixed or adjusted doses. Thus, 890 patients received >= 50 mg/day (high dose group) and 392 were given = 8 mg/day and 85 at doses = 8 mg/day) for retention rates and illicit opioid use, but similar to high doses of buprenorphine (>= 8 mg/day) for both parameters. Patients treated with LAAM had more risk of failure of retention than those receiving high doses of methadone (OR 1.92, 95% CI 1.32-2.78). It is proposed that in agonist-maintenance programmes, oral methadone at doses of 50 mg/day or higher is the drug of choice for opioid dependence. (Author's abstract.) |
Note de contenu : | tabl. ; graph. |
Domaine : | Drogues illicites / Illicit drugs |
Sous-type de document : | Revue de la littérature / Literature review |
Refs biblio. : | 54 |
Affiliation : |
Pharmacol. Unit, Carrer Dc Aiguador 80, 08003 Barcelona Espagne. Spain. |
Numéro Toxibase : | 803761 |
Centre Emetteur : | 08 CAS Strasbourg |
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