| Titre : | Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone |
| Titre traduit : | (Sevrage d'opiacés en prison : utilisation de la méthadone ou de la lofexidine dans un essai contrôlé en double-aveugle) |
| Auteurs : | HOWELLS C. ; S. ALLEN ; J. GUPTA ; G. STILLWELL ; J. MARSDEN ; M. FARRELL |
| Type de document : | Périodique |
| Année de publication : | 2002 |
| Format : | 169-176 / tabl. |
| Note générale : |
Drug and Alcohol Dependence, 2002, 67, (2), 169-176 |
| Langues: | Anglais |
| Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
| Mots-clés : |
Thésaurus TOXIBASE OPIACES ; METHADONE ; AGONISTE ; SEVRAGE ; COMPARAISON ; ESSAI THERAPEUTIQUE ; PRISON |
| Résumé : |
ENGLISH : This paper reports results from the first controlled trial of opioid withdrawal treatment in the UK using lofexidine in a prison setting. Seventy-four opioid dependent male inmates at a Southern England prison were randomised to receive either methadone (the standard prison treatment) or lofexidine using a randomised double-blind design. No significant statistical difference between the treatment groups was found in relation to the primary variable of severity of withdrawal symptoms (effect size = 0.12). No discernible difference was found in the sitting blood pressure or heart rate of the two groups during the trial. These results provide support for the use of lofexidine for the management of opioid detoxification in the prison setting. (Review's abstract.) |
| Note de contenu : | tabl. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 24 |
| Affiliation : |
Natl Addict. Ctr., Inst. Psychiatr., 4 Winsdor Walk, SE5 8AF, London Etats-Unis. United States. |
| Numéro Toxibase : | 804117 |
| Centre Emetteur : | 08 CAS Strasbourg |
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