Titre : | Treating hepatitis C in methadone maintenance patients : an interim analysis) |
Titre traduit : | (Traitement de l'hépatite C chez les patients sous méthadone : étude intermédiaire) |
Auteurs : | D. L. SYLVESTRE |
Type de document : | Périodique |
Année de publication : | 2002 |
Format : | 117-123 / tabl. |
Note générale : |
Drug and Alcohol Dependence, 2002, 67, (2), 117-123 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés HEPATITE ; TRAITEMENT ; ANTIVIRAUX ; USAGER ; TRAITEMENT DE MAINTENANCE |
Résumé : |
ENGLISH : Objective: This study evaluates the safety, tolerability, and efficacy of interferon/ribavirin combination therapy in methadone maintenance (MM) patients with active hepatitis C (HCV). End-of-treatment results are presented as an interim analysis of efficacy. Methods: Fifty eligible MM patients with active HCV and concomitant liver fibrosis were treated with interferon/ribavirin combination therapy using standard dosing regimens. Patients with active drug or alcohol use at the start of treatment, severe or untreated psychiatric illness, and/or decompensated liver disease were excluded. Results: Treated MM patients were older, had a longer history of HCV infection, a high prevalence of psychiatric illness, and had substantially more liver fibrosis than in previous studies of HCV treatment in non-opioid-dependent populations. Seventy-eight percent completed the 6-12 month course of treatment. The end-of-treatment virologic response rate was 64% in patients completing treatment and 54% on an intent-to-treat basis. Conclusion: Methadone maintenance patients exhibit a number of factors that make HCV treatment more difficult: they are older, have a higher prevalence of psychiatric illness, and show evidence of more advanced liver disease. Despite this, their end-of-treatment response rate to interferon/ribavirin combination therapy is similar to that of patients without a history of IDU. Further analysis of the sustained virologic response (SVR) rate is planned at the study's completion. These preliminary results show that MM patients are in need of timely HCV diagnosis, and should be considered good candidates for referral and HCV treatment. (Review's abstract.) |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 29 |
Affiliation : |
Dept. Med., Univ. CA, San Francisco, OASIS, 2862 Telegraph Ave., Oakland, CA 94609 Etats-Unis. United States. |
Numéro Toxibase : | 804113 |
Centre Emetteur : | 08 CAS Strasbourg |
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