Titre : | Rapid detoxification from opioid dependence under general anaesthesia versus standard methadone tapering: abstinence rates and withdrawal distress experiences |
Titre traduit : | (Désintoxication rapide des opioïdes sous anesthésie générale versus diminution progessive des doses de méthadone : taux d'abstinence et symptômes de sevrage désagréables.) |
Auteurs : | P. F. M. KRABBE ; J. P. F. KONING ; HEINEN N. ; R. J. F. LAHEIJ ; VICTORY VAN CAUTER R. M. ; C. A. J. DE JONG |
Type de document : | Périodique |
Année de publication : | 2003 |
Format : | 351-358 / fig. ; tabl. |
Note générale : |
Addiction Biology, 2003, 8, (3), 351-358 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés CURE DE DESINTOXICATION ; DESINTOXICATION ; OPIACES ; COMPARAISON ; ANESTHESIE ; METHADONE ; EFFICACITE ; ABSTINENCE ; SYNDROME DE SEVRAGE |
Résumé : |
ENGLISH : The aim of this work was to study abstinence rates and withdrawal effects of rapid detoxification of opioid-dependents under general anaesthesia (RD-GA) compared to standard methadone tapering (SMT) using a prospective clinical trial with a follow-up of 3 months, as a preliminary study at the Novadic addiction centre in St Oedenrode and St Joseph Hospital in Veghel, the Netherlands. Thirty opioid-dependent patients took part. Outcome measures included urine toxicology screening for opiates to determine abstinence and presence of objective and subjective opioid withdrawal distress symptoms. Statistically significant differences in abstinence rate between RD-GA and SMT were present after one (RD-GA 100% vs. SMT 40%, p |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 29 |
Affiliation : |
Dept Med. Technology Assessment (253), Univ. Med. Ctre Nijmegen, POB 9101, 6500 HB Nijmegen. E-mail: p.krabbemta.umcn.nl Pays-Bas. Netherlands. |
Numéro Toxibase : | 207045 |
Centre Emetteur : | 02 Coordonnateur |
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