| Titre : | Tuberculosis risk varies with the duration of HIV infection: a prospective study of european drug users with known date of HIV seroconversion |
| Titre original: | (Les risques de tuberculose varient avec la durée d'infection au VIH : une étude prospective sur les usagers de drogue européens dont la date de séroconversion VIH est connue) |
| Auteurs : | L. VAN ASTEN ; M. LANGENDAM ; R. ZANGERLE ; I. HERNANDEZ-AGUADO ; F. BOUFASSA ; V. SCHIFFER ; R. P. BRETTLE ; J. ROY ROBERTSON ; FONTANET A. ; R. A. COUTINHO ; M. PRINS |
| Type de document : | Périodique |
| Année de publication : | 2003 |
| Format : | 1201-1208 / tabl. |
| Note générale : |
Aids, 2003, 17, (8), 1201-1208
|
| Langues: | Anglais |
| Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
| Mots-clés : |
Thésaurus TOXIBASE TUBERCULOSE ; VIH ; INCIDENCE ; DUREE ; USAGER ; VOIE INTRAVEINEUSEThésaurus Géographique EUROPE |
| Résumé : |
ENGLISH :
Background: It is not known whether the risk of active tuberculosis disease varies with the length of time that individuals are infected with HIV. Objective: To study how, independently of CD4 T cell count, the risk of tuberculosis varies with the duration of HIV infection. Methods: Using Poisson regression analysis, the incidence of and risk factors for tuberculosis were studied in 683 injecting drug users (IDU) with a documented date of HIV seroconversion followed in seven cohorts in six European countries until 1998. Results: Overall incidence was 11.5/t000 person-years. Adjusted for CD4 T cell count and geographic region, the risk ratio (RR) for tuberculosis (both pulmonary and extrapulmonary), compared with the first 3 years of HIV infection, was 2.8 for years 4 to 6 of HIV infection [95% confidence interval (CI), 1.3-6.3], 1.2 for year 7 to 9 (95% CI, 0.3-4.2) and 4.6 after 9 years (95% CI, 1.4-15.0). The adjusted RR for geographic region was l3.1 (95% CI, 4.3-40,0) for Amsterdam and 15.8 (95% CI, 4.8-52.0) for the Valencian region of Spain compared with all other sites combined. Conclusion: The risk of tuberculosis is increased relatively early in HIV infection (year 4 to 6) and also later (after year 9) with possibly a relatively silent period between. As expected, IDU in Southern Europe have a substantially higher risk of tuberculosis than IDU in Northern and Central Europe. Amsterdam forms an exception for Northern Europe, with very high incidence rates. (Review' s abstract) |
| Note de contenu : | tabl. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 34 |
| Affiliation : | Municipal Hlth Serv. Amsterdam, Cluster Infectious Diseases, Nieuwe Achtergracht 100, 1018 WT Amsterdam Pays-Bas. Netherlands. |
| Numéro Toxibase : | 206964 |
| Centre Emetteur : | 02 Coordonnateur |
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