Titre : | Non-acute (residual) neurocognitive effects of cannabis use: a meta-analytic study |
Titre traduit : | (Effets neurocognitifs résiduels associés à l'usage de cannabis : une méta-analyse.) |
Auteurs : | I. GRANT ; R. GONZALEZ ; C. L. CAREY ; NATARAJAN L. ; T. WOLFSON |
Type de document : | Périodique |
Année de publication : | 2003 |
Format : | 679-689 / fig. ; tabl. |
Note générale : |
Journal of the International Neuropsychological Society, 2003, 9, 679-689 |
Langues: | Anglais |
Mots-clés : |
Thésaurus mots-clés CANNABIS ; SYSTEME NERVEUX CENTRAL ; NEUROLOGIE ; EFFET SECONDAIRE |
Résumé : |
ENGLISH : The possible medicinal use of cannabinoids for chronic diseases emphasizes the need to understand the long-term effects of these compounds on the central nervous system. We provide a quantitative synthesis of empirical research pertaining to the non-acute (residual) effects of cannabis on the neurocognitive performance of adult human subjects. Out of 1,014 studies retrieved using a thorough search strategy, only 11 studies met essential a priori inclusion criteria, providing data for a total of 623 cannabis users and 409 non- or minimal users. Neuropsychological results were grouped into 8 ability domains, and effect sizes were calculated by domain for each study individually, and combined for the full set of studies. Using slightly liberalized criteria, an additional four studies were included in a second analysis, bringing the total number of subjects to 1,188 (i.e., 704 cannabis users and 484 non-users). With the exception of both the learning and forgetting domains, effect size confidence intervals for the remaining 6 domains included zéro, suggesting a lack of effect. Few studies on the non-acute neurocognitive effects of cannabis meet current research standards; nevertheless, our results indicate that there might be decrements in the ability to learn and remember new information in chronic users, whereas other cognitive abilities are unaffected. However, from a neurocognitive standpoint, the small magnitude of these effect sizes suggests that if cannabis compounds are found to have therapeutic value, they may have an acceptable margin of safety under the more Iimited conditions of exposure that would likely obtain in a medical setting. (Review' s abstract) |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 54 |
Affiliation : |
Univ. California, Ctr Medecinal Cannabis Res., 150 West Washington St., San Diego, CA 92103 Etats-Unis. United States. |
Numéro Toxibase : | 206831 |
Centre Emetteur : | 02 Coordonnateur |
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