Titre : | Use of very low-dose naltrexone during opiate detoxification |
Titre traduit : | (Utilisation de naltrexone à très faible dose au cours de la désintoxication aux opiacés.) |
Auteurs : | P. MANNELLI ; E. GOTTHEIL ; A. BUONANNO ; DE RISIO S. |
Type de document : | Périodique |
Année de publication : | 2003 |
Format : | 63-69 / fig. ; tabl. |
Note générale : |
Journal of Addictive Diseases, 2003, 22, (2), 63-69 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés OPIACES ; DESINTOXICATION ; CURE DE DESINTOXICATION ; NALTREXONE ; ANTAGONISTE ; MANQUE ; EFFICACITE |
Résumé : |
ENGLISH : The use of antagonist drugs to reduce the duration of opiate detoxification severely enhances withdrawal symptoms. To investigate the feasibility of administering antagonists with opiates without intense withdrawal during detoxification, 5 methadone maintained patients were evaluated while tapering methadone and receiving at the same time very low (0.125 mg), then increasing daily doses of naltrexone in the course of a 6-day, day hospital treatment. Reduced quantities of adjunctive medications were administered, as compared to the standard protocols, the treatment was completed without incidents or particular discomfort and all patients were easily induced to naltrexone maintenance by the day of discharge. Controlled studies will clarify whether very low-dose naltrexone provides a safe and comfortable detoxification technique to reduce withdrawal intensity and duration without the problems of heavy sedation, as suggested by the description of these clinical cases. (Author' s abstract) |
Note de contenu : | fig. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Affiliation : |
Dept Psychiatry Human Behavior, Thomas Jefferson Univ., 833 Chestnut E.#210E, Philadelphia, PA 19107. E-mail: pmannellikatamail.com Etats-Unis. United States. |
Numéro Toxibase : | 206841 |
Centre Emetteur : | 02 Coordonnateur |
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