Titre : | A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicite cocaine and opiate use in methadone-maintained patients |
Titre traduit : | (Une enquête préliminaire, contrôlée, concernant l'efficacité du magnesium L-aspartate hydrochloride pour diminuer l'usage illicite de cocaine ou d'opiacés chez des patients en traitement de maintenance à la méthadone.) |
Auteurs : | A. MARGOLIN ; KANTAK K. ; COPENHAVER M. ; S. K. AVANTS |
Type de document : | Périodique |
Année de publication : | 2003 |
Format : | 49-61 / tabl. |
Note générale : |
Journal of Addictive Diseases, 2003, 22, (2), 49-61 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés COCAINE ; OPIACES ; MANQUE ; TRAITEMENT ; RECHERCHE |
Résumé : |
ENGLISH : Based on pre-clinical studies suggesting that magnesium (Mg) reduces cocaine self-administration and potentiates the antinociceptive effects of morphine, we conducted a preliminary randomized clinical trial investigating Mg for the treatment of illicit cocaine and opiate use. Eighteen methadone-maintained patients who used illicit opiates and cocaine received either Mg (732 mg/day) or placebo for 12 weeks. Overall, findings showed that the percentage of urine screens testing positive for opiates in the Mg group (22.6%) was half that of the placebo group (46.4%), p = .04; the difference was even greater in the "medication compliant" sample (Mg: 16.3%, placebo: 47,9%), p= .02. Cocaine craving was lower in the Mg compared to the placebo group, but there was no difference between groups in cocaine use. These preliminary findings suggest that Mg may have a beneficial effect for reducing illicit opiate use. It is possible that a higher dose of Mg than was used in this study may be needed to decrease cocaine use. (Author' s abstract) |
Note de contenu : | tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 35 |
Affiliation : |
Yale Univ. Sch. Med., Dept Psychiatry, Substance Abuse Ctr, 34 Park Street, New Haven, CT 06519. E-mail: arthur.margolinyale.edu Etats-Unis. United States. |
Numéro Toxibase : | 206840 |
Centre Emetteur : | 02 Coordonnateur |
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