Titre : | Opiate maintenance with buprenorphine in ambulatory care: a 24-week follow-up study of new users |
Titre traduit : | (Traitement de maintenance ambulatoire des usagers d'opiacés par la buprénorphine : suivi à 24 semaines des nouveaux patients) |
Auteurs : | M. LAPEYRE-MESTRE ; LLAU M. E. ; M. GONY ; NAVEL A. M. ; J. BEZ ; M. GRAU ; J. L. MONTASTRUC |
Type de document : | Périodique |
Année de publication : | 2003 |
Format : | 297-303 / graph. ; tabl. |
Note générale : |
Drug and Alcohol Dependence, 2003, 72, (3), 297-303 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés BUPRENORPHINE ; TRAITEMENT DE MAINTENANCE ; SUIVI DU PATIENT ; OBSERVANCE DU TRAITEMENT ; RETENTION ; COHORTEThésaurus géographique FRANCE |
Résumé : |
ENGLISH : Background: Many studies suggest that buprenorphine, a long acting partial opioid agonist, may be comparable to methadone in efficacy, with fewer withdrawal symptoms and a lower risk of overdose. The aim of this study was to assess the patterns of buprenorphine prescription use in ambulatory care and retention rate under treatment during a 24-week follow-up period. Methods: This observational cohort study included buprenorphine users identified from the French Health System prescription database in an area of 1 million inhabitants and followed for 24 weeks. Results: We selected 282 users of buprenorphine defined as "new users" (74% male, mean age 32.4 +- 6.2 years). Three groups were defined: 50% of "rational users" (141 subjects, no more than 2 prescribers), 24% of "occasional users" (67 subjects, less than 2 buprenorphine prescriptions) and 26% of "non-rational users" (74 subjects, 3 or more prescribers). The overall 24-week treatment retention rate was 37%. Misuse of buprenorphine or benzodiazepines was significantly more frequent in "non-rational" than "rational users". Conclusion: The retention rate with buprenorphine estimated in this observational study was very similar to that obtained in controlled trials. A majority of regular users of buprenorphine could be regarded as "rational users" in this area of France. (Review's abstract.) |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 27 |
Affiliation : |
CEIP, 37 allée J. Guesde, 31073 Toulouse Cedex 7 France. France. |
Numéro Toxibase : | 804466 |
Centre Emetteur : | 08 CAS Strasbourg |
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