Historique
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CD4 cell and CD8 cell-mediated resistance to HIV-1 infection in exposed uninfected intravascular drug users in Vietnam
(Le rôle des cellules CD4 et CD8 dans la résistance au VIH-1 chez des usagers de drogues vietnamiens, exposés au virus mais non contaminés.)
Auteur(s) :
TRUONG L. X. ;
LUONG T. T. ;
SCOTT-ALGARA, D. ;
VERSMISSE P. ;
DAVID, A. ;
PEREZ-BERCOFF, D. ;
NGUYEN, N. V. ;
TRAN, H. K. ;
CAO, C. T. ;
FONTANET A. ;
FOLLEZOU J.-Y. ;
THEODOROU I. ;
BARRE-SINOUSSI, F. ;
PANCINO G.
Année :
2003
Page(s) :
1425-1434
Langue(s) :
Anglais
ISBN :
0269-9370
Refs biblio. :
59
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
VIH
;
SEROPOSITIVITE
;
FACTEUR DE PROTECTION
;
SYSTEME IMMUNITAIRE
;
LYMPHOCYTES
;
INJECTION
Thésaurus géographique
VIETNAM
Note générale :
AIDS, 2003, 17, 1425-1434
Note de contenu :
fig.
Résumé :
ENGLISH :
Objective: To identify mechanisms of resistance to HIV-1 infection in exposed uninfected individuals. Design: We examined in-vitro cell susceptibility to HIV-1 infection in highly exposed Vietnamese intravascular drug users (IDU) who, despite a history of more than 10 years of drug use and a high prevalence of other blood-borne viral infections, remain apparently HIV uninfected. Methods: Forty-five exposed uninfected IDU and 50 blood donors were included in the study. Peripheral blood mononuclear cells (PBMC) or CD4 cell susceptibilities to HIV infection were evaluated using three HIV-1 isolates with different tropisms. Polymerase chain reaction analysis of HIV 1-DNA replication intermediates was used to characterize the restriction of HIV-1 replication in CD4 cells. Homologous CD8 cells were mixed with infected CD4 cells to evaluate their role in virus suppression. Results: We observed a relative resistance to PBMC infection with HIV 1 in 21 out of 45 exposed uninfected IDU, but only in five out of 50 unexposed controls (P
Affiliation :
Unité Biologie des Rétrovirus, Inst. Pasteur, 25 rue du Dr. Roux, 75725 Paris cedex 15. E-mail: gpancinopasteur.fr
France. France.
France. France.