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Maintenance treatment with depot opioid antagonists in subcutaneous implants: an alternative in the treatment of opioid dependence
(Un traitement de maintenance par des implants sous-cutanés d'antagonistes opioïdes : une alternative dans le traitement de la dépendance aux opioïdes.)
Auteur(s) :
J. E. CARRENO ;
C. E. ALVAREZ ;
G. I. SAN NARCISO ;
M. T. BASCARAN ;
DIAZ M. ;
J. BOBES
Article en page(s) :
429-438
Refs biblio. :
54
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Note générale :
Addiction Biology, 2003, 8, (4), 429-438
Note de contenu :
fig. ; graph. ; ill. ; tabl.
Résumé :
ENGLISH :
A report is presented of treatment of 156 patients (male 98%) with opioid dependence (ICD-10 criteria) using a maintenance programme with depot opioid antagonists (naltrexone) as subcutaneous implants, started after an outpatient rapid antagonization regimen. The retention index in the treatment was from 80% in the sixth month, and 65 % after one year. The patients were followed-up for 1 year after discharge. For 6 months after discharge 55.4% were still returning for follow-up visits and 20.8% after 1 year, all of them remaining abstinent to opioids. It is concluded that the programme is safe for the patients and shows a better retention index than programmes using oral antagonists, with an improved compliance (negative urine analysis) compared to the latter. (Author' s abstract)
ENGLISH :
A report is presented of treatment of 156 patients (male 98%) with opioid dependence (ICD-10 criteria) using a maintenance programme with depot opioid antagonists (naltrexone) as subcutaneous implants, started after an outpatient rapid antagonization regimen. The retention index in the treatment was from 80% in the sixth month, and 65 % after one year. The patients were followed-up for 1 year after discharge. For 6 months after discharge 55.4% were still returning for follow-up visits and 20.8% after 1 year, all of them remaining abstinent to opioids. It is concluded that the programme is safe for the patients and shows a better retention index than programmes using oral antagonists, with an improved compliance (negative urine analysis) compared to the latter. (Author' s abstract)
Affiliation :
Clinica Médico Psicologica Asturias, C/Asturias, 8-5a planta, 33206 Gijon, Asturias. Email : cmedicotelecable.es
Espagne. Spain.
Espagne. Spain.
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