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Drug interactions between opioids and antiretroviral medications : interaction between methadone, LAAM, and nelfinavir
(Interactions chimiques entre les opioïdes et les médicaments antirétroviraux : interaction entre la méthadone, la LAAM et le nelfinavir.)
Auteur(s) :
McCANCE-KATZ, E. F. ;
RAINEY P. M. ;
SMITH, P. ;
MORSE G. ;
FRIEDLAND G. ;
GOUREVITCH, M. N. ;
JATLOW P.
Année :
2004
Page(s) :
163-180
Langue(s) :
Anglais
Refs biblio. :
47
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
INTERACTION CHIMIQUE
;
ANTIRETROVIRAUX
;
TRAITEMENT
;
METHADONE
;
LAAM
;
PHARMACOCINETIQUE
Note générale :
American Journal on Addictions, 2004, 13, (2), 163-180
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Understanding drug interactions between antiretrovirals and opiate therapies may decrease toxicities and enhance adherence, with improved HIV outcomes in injection drug users. We report results of a clinical pharmacology study designed to examine the interaction of the protease inhibitor, nelfinavir, with methadone and LAAM (N = 48). Nelfinavir decreased methadone exposure, but no withdrawal was observed over the five day study period. LAAM and dinorLAAM concentrations were decreased, while norLAAM concentrations were increased, with minimal overall change in LAAM/metabolite exposure. Methadone and LAAM did not affect nelfinavir concentrations, but methadone decreased M8 metabolite exposure. While no toxicities were observed, clinicians should be aware of the potential for drug interactions when patients require treatment with nelfinavir and these opiate medications. (Review' s abstract)
Affiliation :
Medical College of Virginia, Virginia Commonwealth University, PO Box 980109, Richmond VA 23298 ; emccancekatzvcu.edu
Etats-Unis. United States.
Etats-Unis. United States.