Historique
Périodique
Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administratiob by humans
(La maintenance à la gabapentine diminue les effets subjectifs de la cocaïne fumée, mais ne diminue pas l'autoadministration chez l'homme)
Auteur(s) :
C. L. HART ;
A. S. WARD ;
E. D. COLLINS ;
M. HANEY ;
R. W. FOLTIN
Article en page(s) :
279-287
Refs biblio. :
29
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Note générale :
Drug and Alcohol Dependence, 2004, 73, (3), 279-287
Note de contenu :
fig.
Résumé :
ENGLISH :
Data from research with laboratory animals indicate that cocaine self-administration can be reduced by A-aminobutyric acid (GABA) agonists. Yet, the effectiveness of GABA agonists to decrease human cocaine self-administration has not been investigated under controlled laboratory conditions. The purpose of this study was to assess the effects of gabapentin, a GABA agonist, on cocaine-related behaviors, including self-administration, in human research participants under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of gabapentin (0, 600, and 1200 mg/d) maintenance on response to cocaine (0, 12, 25, and 50 mg) were investigated in seven cocaine abusers. Active cocaine significantly increased choice to self-administer cocaine, subjective-effect ratings (e.g., "Good Drug Effect"), blood pressure and heart rate (HR). Gabapentin did not reduce cocaine choice or cardiovascular measures, but it did decrease some subjective effects of cocaine (e.g., "Good Drug Effect" and "Anxious"). These data suggest that the cocaine-gabapentin combination was well-tolerated, and because some cocaine-related subjective effects were reduced by maintenance on relatively low gabapentin doses, future studies should test higher gabapentin doses. (Review's abstract.)
ENGLISH :
Data from research with laboratory animals indicate that cocaine self-administration can be reduced by A-aminobutyric acid (GABA) agonists. Yet, the effectiveness of GABA agonists to decrease human cocaine self-administration has not been investigated under controlled laboratory conditions. The purpose of this study was to assess the effects of gabapentin, a GABA agonist, on cocaine-related behaviors, including self-administration, in human research participants under controlled laboratory conditions. During this 48-day double-blind, crossover design study, the effects of gabapentin (0, 600, and 1200 mg/d) maintenance on response to cocaine (0, 12, 25, and 50 mg) were investigated in seven cocaine abusers. Active cocaine significantly increased choice to self-administer cocaine, subjective-effect ratings (e.g., "Good Drug Effect"), blood pressure and heart rate (HR). Gabapentin did not reduce cocaine choice or cardiovascular measures, but it did decrease some subjective effects of cocaine (e.g., "Good Drug Effect" and "Anxious"). These data suggest that the cocaine-gabapentin combination was well-tolerated, and because some cocaine-related subjective effects were reduced by maintenance on relatively low gabapentin doses, future studies should test higher gabapentin doses. (Review's abstract.)
Affiliation :
Div. Sub. Abuse., New York State Psychiatr. Inst. Dept. Psychiatr., Columbia Univ., 1051 Riverside Dr., Unit 120, NY 10032
Etats-Unis. United States.
Etats-Unis. United States.
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