Titre : | Effects of 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) on the self-administration of cocaine, heroin, and cocaine/heroin combinations in rats |
Titre traduit : | (Action du 2béta-propanoyl-3béta-(4-tolyl)-tropane (PTT) sur l'autoadministration de cocaine, d'héroïne ou des deux drogues chez le rat) |
Auteurs : | SIZEMORE G. M. ; H. M. L. DAVIES ; T. J. MARTIN ; J. E. SMITH |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 259-265 / fig. |
Note générale : |
Drug and Alcohol Dependence, 2004, 73, (3), 259-265 |
Langues: | Anglais |
Discipline : | PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods) |
Mots-clés : |
Thésaurus mots-clés HEROINE ; COCAINE ; NEUROTRANSMETTEURS ; AUTOADMINISTRATION ; MODELE ANIMAL |
Résumé : |
ENGLISH : Pharmacotherapies utilizing long-acting agonists and mixed function agonists-antagonists have been successful in the treatment of opiate addiction but no comparable treatment exists for cocaine abuse. Long-acting tropane analogues have been synthesized that could be candidates for such pharmacotherapies. 2beta-Propanoyl-3beta-(4-tolyl)-tropane (PTT) is one such compound that is a relatively selective dopamine (DA) transporter blocker that has a significantly longer duration of action than cocaine. The purpose of this study was to assess the effects of PTT on the intravenous self-administration of cocaine, heroin, or cocaine/heroin combinations. Groups of rats were trained to self-administer cocaine, heroin, or cocaine/heroin combinations using a within session dosing procedure in which three doses were available each session. PTT pretreatment reduced cocaine and cocaine/heroin combinations intake in a dose-dependent manner while having only minor effects on heroin intake. These results suggest that the neurobiological substrates of cocaine and heroin self-administration are different, and that these cocaine/heroin combinations may function more like cocaine alone, even when the dose of heroin in the mixture will function independently as a reinforcer. These results further support the potential use of long-acting dopamine reuptake inhibitors as pharmacotherapeutic adjuncts to a comprehensive treatment program for cocaine and cocaine/heroin abuse. (Review's abstract.) |
Note de contenu : | fig. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 39 |
Affiliation : |
Dept. Physiol. Pharmacol., Wake Forest Univ. Hlth Sci., Med. Ctr. Bld. Winston-Salem, NC 27157-1083 Etats-Unis. United States. |
Numéro Toxibase : | 804604 |
Centre Emetteur : | 08 CAS Strasbourg |
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