Historique
Périodique
Cortical gray matter volumes are associated with subjective responses to cocaine infusion
(Les volumes de matière grise corticale sont associés avec les réponses subjectives induites par la cocaïne.)
Auteur(s) :
BARTZOKIS, G. ;
BECKSON, M. ;
LU, P. H. ;
EDWARDS, N. ;
RAPOPORT, R. ;
BRIDGE, P. ;
MINTZ, J.
Année :
2004
Page(s) :
64-73
Langue(s) :
Anglais
Refs biblio. :
30
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
American Journal on Addictions, 2004, 13, (1), 64-73
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
We analyzed the relationship between cocaine-induced euphoria and measures of frontal and temporal gray matter volumes in eleven cocaine-dependent (CD) patients two underwent magnetic resonance imaging (MRI). Self-reported ratings of the intensity of euphoric response to cocaine infusion were obtained from the CD subjects at 3, 10, and 30 minutes after cocaine infusion. Significant positive correlation betmeen frontal and temporal cortical gray matter volume and the intensity of euphoria was observed at 10 minutes after IV cocaine. The data suggest that frontal and temporal lobe gray matter volume is associated with some of the reinforcing effects of cocaine. Given the well-established negative linear relationship between cortical gray matter volume and age, cortical gray matter volume may be a marker for the neurobiological substrate of the age-related reduction in addiction rates.
Affiliation :
Dr Bartzokis, UCLA Alzheimer's Disease Center, 710 Westwood Plaza, Room 2-238, Los Angeles, CA 90095-1769 ; gbarucla.edu
France. France.
France. France.