Titre : | A randomized, placebo-controlled trial of buspirone for the treatment of anxiety in opioid-dependant individuals |
Titre traduit : | (Un essai randomisé, contre placebo, sur l'efficacité de la buspirone dans le traitement de l'anxiété chez des usagers dépendants des opioïdes.) |
Auteurs : | A. L. MCRAE ; S. C. SONNE ; K. T. BRADY ; DURKALSKI V. ; PALESCH Y. |
Type de document : | Périodique |
Année de publication : | 2004 |
Format : | 53-63 / graph. ; tabl. |
Note générale : |
American Journal on Addictions, 2004, 13, (1), 53-63 |
Langues: | Anglais |
Discipline : | TRA (Traitement et prise en charge / Treatment and care) |
Mots-clés : |
Thésaurus mots-clés ANXIETE ; DEPRESSION ; TRAITEMENT DE MAINTENANCE ; ANXIOLYTIQUES ; EFFICACITE |
Résumé : |
ENGLISH : Anxiety symptoms are common among opioid dependent individuals. Buspirone, a non benzodiazepine anxiolytic, has been used successfully for the treatment of anxiety in alcoholic patients. Its efficacy in opioid-dependent patients has not been previously examined. We conducted a twelve-week, randomized, placebo-controlled trial of buspirone in 36 subjects receiving methadone-maintenance treatment who presented with anxiety symptoms. Measures of anxiety, depression, and substance use were obtained repeatedly during treatment. Buspirone treatment did not significantly reduce anxiety symptoms in opioid-dependent patients. However, buspirone treatment was associated with trends toward reduction in depression scale scores and a slower return to substance use. (Review' s abstract) |
Note de contenu : | graph. ; tabl. |
Domaine : | Drogues illicites / Illicit drugs |
Refs biblio. : | 29 |
Affiliation : |
Dr Mc Rae, Clinical Res. Neuroscience Div., 61 President St., Charleston, SC 29425 ; mcraealmusc.edu. Etats-Unis. United States. |
Numéro Toxibase : | 207264 |
Centre Emetteur : | 02 Coordonnateur |
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