| Titre : | Treatment of hepatitis C in HIV-infected patients. Significant progress but not the final step |
| Titre traduit : | (Traitement de l'hépatite C chez des patients infectés par le VIH. Des progrès significatifs ont été faits, mais la dernière marche n'est pas atteinte.) |
| Auteurs : | MANNS M. P. ; H. WEDEMEYER |
| Type de document : | Périodique |
| Année de publication : | 2004 |
| Format : | 2909-2913 / tabl. |
| Note générale : |
JAMA, 2004, 292, (23), 2909-2913 |
| Langues: | Anglais |
| Discipline : | MAL (Maladies infectieuses / Infectious diseases) |
| Mots-clés : |
Thésaurus mots-clés HEPATITE ; ANTIRETROVIRAUX ; VIH ; TRAITEMENT ; ESSAI THERAPEUTIQUE |
| Résumé : |
ENGLISH : In the modern era of highly active antiretroviral therapy (HAART), hepatitis C virus (HCV) has emerged as a major cause of morbidity and death in human immunodeficiency virus (HIV) infection. An estimated 15% to 30% of HIV-infected individuals are coinfected with HCV, representing 150 000 to 300 000 patients in the United States alone.The prevalence of anti-HCV antibodies in HIV-infected persons differs significantly according to the HIV-exposure risk category, ranging from less than 10% in homosexual men to more than 85% in injecting drug users. In the vast majority of immunocompetent nonHIV-infected persons, chronic hepatitis C usually takes a relatively mild course, leading to liver cirrhosis in 2% to 25% after 20 to 25 years depending on the individual risk factor profile. Liver-related death is only slightly more frequent in HCV-infected individuals. In contrast, hepatitis C may take a much more severe course in HIV-infected patients. (Extract of the publication) |
| Note de contenu : | tabl. |
| Domaine : | Drogues illicites / Illicit drugs |
| Refs biblio. : | 45 |
| Affiliation : |
Dprt of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School (MHH), Carl-Neuberg Strasse 1, D-30625 Hannover. Email : manns.michaelmh-hannover.de Allemagne. Germany. |
| Numéro Toxibase : | 208008 |
| Centre Emetteur : | 02 Coordonnateur |
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