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Quantitative drug levels in stimulant psychosis: relationship to symptom severity, catecholomines and hyperkinesia
(Evaluation quantitative des taux de drogues dans les psychoses induites par les stimulants : relation avec la gravité des symptômes, les catécholamines et l'hyperkinésie.)
Auteur(s) :
S. L. BATKI ;
D. S. HARRIS
Article en page(s) :
461-470
Refs biblio. :
45
Domaine :
Drogues illicites / Illicit drugs
Langue(s) :
Anglais
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
TROUBLE BIPOLAIRE
;
AMPHETAMINE
;
PSYCHOSE
;
DOSE-REPONSE
;
SANG
;
URINE
;
CATECHOLAMINES
Note générale :
American Journal on Addictions, 2004, 13, (5), 461-470
Note de contenu :
tabl.
Résumé :
ENGLISH :
To examine the relationship between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric emergency service with a diagnosis of amphetamine- or cocaine-induced psychosis were interviewed, and plasma and urine were collected for quantitative assays of stimulant drug and catecholamine metabolite levels. Methamphetamine or amphetamine levels were related to several psychopathology scores and the global hyperkinesia rating. HVA levels were related to global hyperkinesia but not to psychopathology ratings. Although many other factors such as sensitization may play a role, intensity of stimulant-induced psychotic symptoms and stereotypies appears to be at least in part dose-related. (Author' s abstract)
ENGLISH :
To examine the relationship between quantitative stimulant drug levels, catecholamines, and psychotic symptoms, nineteen patients in a psychiatric emergency service with a diagnosis of amphetamine- or cocaine-induced psychosis were interviewed, and plasma and urine were collected for quantitative assays of stimulant drug and catecholamine metabolite levels. Methamphetamine or amphetamine levels were related to several psychopathology scores and the global hyperkinesia rating. HVA levels were related to global hyperkinesia but not to psychopathology ratings. Although many other factors such as sensitization may play a role, intensity of stimulant-induced psychotic symptoms and stereotypies appears to be at least in part dose-related. (Author' s abstract)
Affiliation :
Dept Psychiatry, Univ. Cincinnati and Cincinnati V.A. Medical Ctr, 3200 Vine St, Cincinnati, OH 45220. E-mail: debra.harrismed.va.gov
Etats-Unis. United States.
Etats-Unis. United States.
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